PMID- 18355201
OWN - NLM
STAT- MEDLINE
DCOM- 20090805
LR  - 20090615
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Linking)
VI  - 22
IP  - 8
DP  - 2008 Aug
TI  - Relationship between periodontal findings and the TNF-alpha Gene 1031T/C 
      polymorphism in Turkish patients with Behcet's disease.
PG  - 950-7
LID - 10.1111/j.1468-3083.2008.02678.x [doi]
AB  - BACKGROUND: Genetic factors that predispose individuals to Behcet's disease (BD) 
      and periodontal disease. Tumour necrosis factor-alpha (TNF-alpha) has been 
      implicated in the pathogenesis of both BD and periodontal disease. The 
      relationship with periodontitis and the pathogenesis of BD has not yet been 
      determined. OBJECTIVE: The aim of the present study was to investigate the 
      possible relation of the periodontal scores and single nucleotide polymorphism of 
      TNF-alpha-1031T/C with BD compared with healthy controls (HC) and recurrent 
      aphtous stomatitis (RAS). We also sought to determine the effects of periodontal 
      condition and TNF-alpha-1031T/C polymorphism on clinical severity of BD. METHODS: 
      Eighty-two unrelated patients with BD, 42 RAS patients and 77 HC were enrolled in 
      the study. Periodontal status of all subjects was evaluated according to the 
      World Health Organization community periodontal index of treatment needs (CPITN). 
      For genotyping, polymerase chain reaction-restriction fragment length 
      polymorphism was employed. RESULTS: The mean CPITN was observed to be higher in 
      patients with BD compared with HC and RAS (P < 0.001). TNF-alpha-1031C allele was 
      significantly higher in patients with BD (P = 0.023) and RAS (P = 0.007) compared 
      with HC. Mean CPITN was higher in CC genotype compared with other genotypes (P = 
      0.004). Moreover, CPITN and CC genotype was found to be correlated with the 
      severity of the disease. CONCLUSIONS: Our data indicate that the 
      TNF-alpha-1031T/C gene polymorphism (CC genotype) is a risk factor for 
      periodontitis, RAS and BD patients and also suggests that long-term periodontal 
      follow-up and education of oral hygiene in patients with BD may help to prevent 
      the development and/or progression of the disease.
FAU - Akman, A
AU  - Akman A
AD  - Department of Dermatology and Venerology, Akdeniz University School of Medicine, 
      Antalya, Turkey.
FAU - Sallakci, N
AU  - Sallakci N
FAU - Kacaroglu, H
AU  - Kacaroglu H
FAU - Tosun, O
AU  - Tosun O
FAU - Yavuzer, U
AU  - Yavuzer U
FAU - Alpsoy, E
AU  - Alpsoy E
FAU - Yegin, O
AU  - Yegin O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080319
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Analysis of Variance
MH  - Behcet Syndrome/*genetics
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Disease Progression
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Periodontal Diseases/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Turkey
EDAT- 2008/03/22 09:00
MHDA- 2009/08/06 09:00
CRDT- 2008/03/22 09:00
PHST- 2008/03/22 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
PHST- 2008/03/22 09:00 [entrez]
AID - JDV2678 [pii]
AID - 10.1111/j.1468-3083.2008.02678.x [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2008 Aug;22(8):950-7. doi: 
      10.1111/j.1468-3083.2008.02678.x. Epub 2008 Mar 19.