PMID- 18355838
OWN - NLM
STAT- MEDLINE
DCOM- 20080820
LR  - 20080505
IS  - 1095-8541 (Electronic)
IS  - 0022-5193 (Linking)
VI  - 252
IP  - 2
DP  - 2008 May 21
TI  - The modified Mahalanobis Discriminant for predicting outer membrane proteins by 
      using Chou's pseudo amino acid composition.
PG  - 350-6
LID - 10.1016/j.jtbi.2008.02.004 [doi]
AB  - The outer membrane proteins (OMPs) are beta-barrel membrane proteins that 
      performed lots of biology functions. The discriminating OMPs from other non-OMPs 
      is a very important task for understanding some biochemical process. In this 
      study, a method that combines increment of diversity with modified Mahalanobis 
      Discriminant, called IDQD, is presented to predict 208 OMPs, 206 transmembrane 
      helical proteins (TMHPs) and 673 globular proteins (GPs) by using Chou's pseudo 
      amino acid compositions as parameters. The overall accuracy of jackknife 
      cross-validation is 93.2% and 96.1%, respectively, for three datasets (OMPs, 
      TMHPs and GPs) and two datasets (OMPs and non-OMPs). These predicted results 
      suggest that the method can be effectively applied to discriminate OMPs, TMHPs 
      and GPs. And it also indicates that the pseudo amino acid composition can better 
      reflect the core feature of membrane proteins than the classical amino acid 
      composition.
FAU - Lin, Hao
AU  - Lin H
AD  - School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu 610054, China. hlin@uestc.edu.cn
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080212
PL  - England
TA  - J Theor Biol
JT  - Journal of theoretical biology
JID - 0376342
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - *Algorithms
MH  - Amino Acid Motifs
MH  - Animals
MH  - Databases, Protein
MH  - *Discriminant Analysis
MH  - Membrane Proteins/*chemistry
MH  - Molecular Conformation
EDAT- 2008/03/22 09:00
MHDA- 2008/08/21 09:00
CRDT- 2008/03/22 09:00
PHST- 2007/11/08 00:00 [received]
PHST- 2007/12/02 00:00 [revised]
PHST- 2008/02/04 00:00 [accepted]
PHST- 2008/03/22 09:00 [pubmed]
PHST- 2008/08/21 09:00 [medline]
PHST- 2008/03/22 09:00 [entrez]
AID - S0022-5193(08)00055-6 [pii]
AID - 10.1016/j.jtbi.2008.02.004 [doi]
PST - ppublish
SO  - J Theor Biol. 2008 May 21;252(2):350-6. doi: 10.1016/j.jtbi.2008.02.004. Epub 
      2008 Feb 12.