PMID- 18356750
OWN - NLM
STAT- MEDLINE
DCOM- 20080703
LR  - 20221207
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 63
IP  - 4
DP  - 2008 Apr
TI  - Cutaneous microvascular dysfunction is associated with human leukocyte antigen-DQ 
      in youths with type 1 diabetes.
PG  - 420-2
LID - 10.1203/PDR.0b013e318165bfd4 [doi]
AB  - Functional disturbances in microcirculation in juvenile type 1 diabetes (T1D) are 
      believed to underlie, in part, the later occurrence of cardiovascular 
      complications. Some epidemiologic studies suggested greater risk of microvascular 
      complications in those with T1D-risk genotypes of human leukocyte antigen (HLA). 
      We investigated whether HLA-DQ2/8, which is linked to highest T1D morbidity, 
      influences microvascular function in young diabetic patients. Cutaneous 
      microvascular endothelium-dependent and independent reactivity and HLA genotypes 
      were assessed in young patients (age: 9-21 y) with T1D (duration: 2-20 y). 
      HLA-DQ2/8 was identified in 29 of 75 patients. The DQ2/8 and non-DQ2/8 groups 
      were similar in age, body mass index, diabetes duration, glycosylated hemoglobin, 
      and C-reactive protein (CRP). Compared with the non-DQ2/8 group, the DQ2/8 group 
      showed decreased endothelium-dependent responses (p = 0.03 after adjustment for 
      age, diabetes duration, glycosylated hemoglobin, and CRP) and elevated soluble 
      intercellular adhesion molecule-1 (p = 0.05). In these but not in non-DQ2/8 
      patients, CRP correlated with both systolic (r = 0.76; p < 0.001) and diastolic 
      (r = 0.50; p = 0.01) blood pressure. HLA-DQ2/8 is associated with endothelial 
      microvascular dysfunction in young patients with T1D, and future studies are 
      needed to provide mechanistic insights. The findings could explain in part the 
      previously reported epidemiologic link between T1D-risk HLA and microvascular 
      complications.
FAU - Odermarsky, Michal
AU  - Odermarsky M
AD  - Pediatric Cardiology, Lund University Hospital, Lund, Sweden 221 85.
FAU - Lernmark, Ake
AU  - Lernmark A
FAU - Truedsson, Lennart
AU  - Truedsson L
FAU - Liuba, Petru
AU  - Liuba P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - C-Reactive Protein/metabolism
MH  - Child
MH  - Diabetes Mellitus, Type 1/complications/*genetics/physiopathology
MH  - Diabetic Angiopathies/etiology/*genetics/physiopathology
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Genotype
MH  - Glycated Hemoglobin/metabolism
MH  - HLA-DQ Antigens/blood/*genetics
MH  - Humans
MH  - Laser-Doppler Flowmetry
MH  - Male
MH  - Microcirculation/physiology
MH  - Risk Factors
MH  - Skin/*blood supply
EDAT- 2008/03/22 09:00
MHDA- 2008/07/04 09:00
CRDT- 2008/03/22 09:00
PHST- 2008/03/22 09:00 [pubmed]
PHST- 2008/07/04 09:00 [medline]
PHST- 2008/03/22 09:00 [entrez]
AID - 00006450-200804000-00016 [pii]
AID - 10.1203/PDR.0b013e318165bfd4 [doi]
PST - ppublish
SO  - Pediatr Res. 2008 Apr;63(4):420-2. doi: 10.1203/PDR.0b013e318165bfd4.