PMID- 18359158
OWN - NLM
STAT- MEDLINE
DCOM- 20080813
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 436
IP  - 2
DP  - 2008 May 9
TI  - Time-dependent change of ERK phosphorylation levels in the nucleus accumbens 
      during withdrawals from repeated cocaine.
PG  - 107-10
LID - 10.1016/j.neulet.2008.02.068 [doi]
AB  - Extracellular signal-regulated kinase (ERK) has been implicated in 
      cocaine-induced behavioral sensitization. We sought to determine whether ERK 
      activation in the nucleus accumbens (NAcc), the site mediating the expression of 
      behavioral sensitization, shows time-dependent changes after cocaine withdrawals. 
      The basal levels of ERK phosphorylation in the NAcc show no changes on withdrawal 
      day 1, while they increase on day 7, then gradually lower down to reach the same 
      level on day 21 in cocaine compared to saline pre-exposed rats. Either total ERK 
      or both phosphorylated and total p38 protein levels are not different in any 
      time-point measurements. These results suggest that such time-dependent ERK 
      activation in the NAcc may contribute to neuronal plasticity leading to 
      long-lasting behavioral changes such as drug craving.
FAU - Kim, Seungwoo
AU  - Kim S
AD  - Department of Physiology, Brain Korea 21 Project for Medical Science, Brain 
      Research Institute, Yonsei University College of Medicine, 134 Shinchondong, 
      Seodaemungu, Seoul 120-752, South Korea.
FAU - Kim, Jeong-Hoon
AU  - Kim JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080305
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Cocaine/*adverse effects
MH  - Dopamine Uptake Inhibitors/*adverse effects
MH  - Extracellular Signal-Regulated MAP Kinases/*metabolism
MH  - Male
MH  - Nucleus Accumbens/drug effects/*enzymology
MH  - Phosphorylation/drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Substance Withdrawal Syndrome/*etiology/pathology
MH  - Time Factors
EDAT- 2008/03/25 09:00
MHDA- 2008/08/14 09:00
CRDT- 2008/03/25 09:00
PHST- 2008/01/15 00:00 [received]
PHST- 2008/02/17 00:00 [revised]
PHST- 2008/02/29 00:00 [accepted]
PHST- 2008/03/25 09:00 [pubmed]
PHST- 2008/08/14 09:00 [medline]
PHST- 2008/03/25 09:00 [entrez]
AID - S0304-3940(08)00277-2 [pii]
AID - 10.1016/j.neulet.2008.02.068 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 May 9;436(2):107-10. doi: 10.1016/j.neulet.2008.02.068. Epub 
      2008 Mar 5.