PMID- 18359328
OWN - NLM
STAT- MEDLINE
DCOM- 20080515
LR  - 20161124
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 101
IP  - 7
DP  - 2008 Apr 1
TI  - Evidence of impaired left ventricular systolic function by Doppler myocardial 
      imaging in patients with systemic amyloidosis and no evidence of cardiac 
      involvement by standard two-dimensional and Doppler echocardiography.
PG  - 1039-45
LID - 10.1016/j.amjcard.2007.11.047 [doi]
AB  - We examined the potential role of Doppler myocardial imaging for early detection 
      of systolic dysfunction in patients with systemic amyloidosis (AL) but without 
      evidence of cardiac involvement by standard echocardiography. We identified 42 
      patients without 2-dimensional echocardiographic or Doppler evidence of cardiac 
      involvement. These patients had normal ventricular wall thickness and normal 
      velocity of the medial mitral annulus. Myocardial images were obtained in these 
      patients and in 32 age- and gender-matched healthy controls. Peak longitudinal 
      systolic tissue velocity (sTVI), systolic strain rate (sSR), and systolic strain 
      (sS) were determined for 16 left ventricular segments. Radial and circumferential 
      sSR and sS were also measured. Compared with controls in this group of patients 
      with AL, peak longitudinal sSR (-1.0 +/- 0.2 vs -1.4 +/- 0.2, p <0.001) and peak 
      longitudinal sS (-15.6 +/- 3.3 vs -22.5 +/- 2.0 p <0.001) were significantly 
      decreased. In conclusion, the mean sS from all 6 basal segments, or from all 16 
      left ventricular segments differentiated patients with AL with normal 
      echocardiography from controls, with similar accuracy for the mean sSR from the 6 
      basal segments. This distinction was not apparent from peak longitudinal sTVI or 
      from radial or circumferential sSI or sSR.
FAU - Bellavia, Diego
AU  - Bellavia D
AD  - Cardiovascular Division, Mayo Clinic and Foundation, Rochester, MN, USA.
FAU - Pellikka, Patricia A
AU  - Pellikka PA
FAU - Abraham, Theodore P
AU  - Abraham TP
FAU - Al-Zahrani, Ghormallah B
AU  - Al-Zahrani GB
FAU - Dispenzieri, Angela
AU  - Dispenzieri A
FAU - Oh, Jae K
AU  - Oh JK
FAU - Bailey, Kent R
AU  - Bailey KR
FAU - Wood, Christina M
AU  - Wood CM
FAU - Lacy, Martha Q
AU  - Lacy MQ
FAU - Miyazaki, Chinami
AU  - Miyazaki C
FAU - Miller, Fletcher A Jr
AU  - Miller FA Jr
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080201
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Aged
MH  - Amyloidosis/complications/*diagnostic imaging
MH  - Case-Control Studies
MH  - Echocardiography, Doppler/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Systole
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/etiology
MH  - *Ventricular Function, Left
EDAT- 2008/03/25 09:00
MHDA- 2008/05/16 09:00
CRDT- 2008/03/25 09:00
PHST- 2007/08/01 00:00 [received]
PHST- 2007/11/13 00:00 [revised]
PHST- 2007/11/13 00:00 [accepted]
PHST- 2008/03/25 09:00 [pubmed]
PHST- 2008/05/16 09:00 [medline]
PHST- 2008/03/25 09:00 [entrez]
AID - S0002-9149(07)02364-8 [pii]
AID - 10.1016/j.amjcard.2007.11.047 [doi]
PST - ppublish
SO  - Am J Cardiol. 2008 Apr 1;101(7):1039-45. doi: 10.1016/j.amjcard.2007.11.047. Epub 
      2008 Feb 1.