PMID- 18359695
OWN - NLM
STAT- MEDLINE
DCOM- 20090402
LR  - 20151119
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 28
IP  - 3
DP  - 2008 Mar
TI  - [Expression of epidermal fatty acid-binding protein and fatty acid synthase in 
      infiltrating ductal breast carcinoma].
PG  - 381-4
AB  - OBJECTIVE: To detect the expression of epidermal fatty acid-binding protein 
      (E-FABP) and fatty acid synthase (FAS) in human breast cancer and identify the 
      potential markers and therapeutic targets for breast cancer. METHODS: FAS and 
      E-FABP expressions were detected in 76 patients with infiltrating ductal breast 
      carcinoma using RT-PCR, immunohistochemistry and Western blotting. The possible 
      associations of the expression of the two proteins with the major 
      clinicopathological factors were analyzed. RESULTS: E-FABP and FAS expression 
      levels were significantly decreased (P<0.05) in grade III as compared with grades 
      I and II infiltrating ductal breast carcinoma. There was a positive correlation 
      between E-FABP and FAS expressions, but their expressions were not correlated to 
      the clinicopathological factors of the patients except for the tumor grades. High 
      E-FABP expression level in grades I and II tumors were associated with an early 
      increased responsiveness to FAS. CONCLUSION: The variation of the E-FABP and FAS 
      expressions in the lesions is associated with increase of the risk for breast 
      cancer, and the results of this study provide evidence for developing new 
      molecular markers of high-risk lesions and identifying new the targets for breast 
      cancer therapy.
FAU - Li, Hua
AU  - Li H
AD  - Department of Anatomy, School of Preclinical and Forensic Medicine, Sichuan 
      University, Chengdu 610041, China. leehua117@yahoo.com.cn
FAU - Lu, Qing
AU  - Lu Q
FAU - Xue, Hui
AU  - Xue H
FAU - Dong, Li-hua
AU  - Dong LH
FAU - Saima, Naz
AU  - Saima N
FAU - Yang, Hui-jun
AU  - Yang HJ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (FABP5 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - EC 2.3.1.85 (Fatty Acid Synthases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/biosynthesis/genetics
MH  - Blotting, Western
MH  - Breast Neoplasms/genetics/metabolism/*pathology
MH  - Carcinoma, Ductal, Breast/genetics/metabolism/*pathology
MH  - Fatty Acid Synthases/*biosynthesis/genetics
MH  - Fatty Acid-Binding Proteins/*biosynthesis/genetics
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Middle Aged
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2008/03/25 09:00
MHDA- 2009/04/03 09:00
CRDT- 2008/03/25 09:00
PHST- 2008/03/25 09:00 [pubmed]
PHST- 2009/04/03 09:00 [medline]
PHST- 2008/03/25 09:00 [entrez]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):381-4.