PMID- 18360615
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20231103
IS  - 1176-6336 (Print)
IS  - 1178-203X (Electronic)
IS  - 1176-6336 (Linking)
VI  - 3
IP  - 1
DP  - 2007 Mar
TI  - Drug management in chronic rhinosinusitis: identification of the needs.
PG  - 47-57
AB  - Chronic rhinosinusitis (CRS) is a group of multifactorial diseases characterized 
      by inflammation of the mucosa of the nose and paranasal sinuses with a history of 
      at least 12 weeks of persistent symptoms despite maximal medical therapy. The 
      precise role played by infection and immunoglobin E (IgE)-mediated 
      hypersensitivity remains unclear. Diagnosis of CRS is based upon medical history, 
      nasal endoscopy and computed tomography scan of the sinuses. The CRS with polyps 
      visible in the middle meatus must be distinguished from the CRS without polyps. 
      Based on the current knowledge about the pathogenesis of CRS, it is admitted that 
      an optimal medical treatment must consider all favorizing factors and control 
      efficaciously the inflammation process. In case of failure of medical treatment, 
      endoscopic sinus surgery should be proposed. However, some well-validated data 
      and scientific evidences are missing, even for the most frequently used 
      medications. After a review of the actual definitions and classifications, a 
      short description of the current knowledge about pathogenesis of CRS is provided 
      in order to justify the actual therapeutic rationales and identify the needs for 
      an effective treatment of CRS.
FAU - Watelet, Jean-Baptiste Hpj
AU  - Watelet JB
FAU - Eloy, Philippe H
AU  - Eloy PH
FAU - van Cauwenberge, Paul B
AU  - van Cauwenberge PB
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Ther Clin Risk Manag
JT  - Therapeutics and clinical risk management
JID - 101253281
PMC - PMC1936288
EDAT- 2008/03/25 09:00
MHDA- 2008/03/25 09:01
PMCR- 2007/07/01
CRDT- 2008/03/25 09:00
PHST- 2008/03/25 09:00 [pubmed]
PHST- 2008/03/25 09:01 [medline]
PHST- 2008/03/25 09:00 [entrez]
PHST- 2007/07/01 00:00 [pmc-release]
AID - 10.2147/tcrm.2007.3.1.47 [doi]
PST - ppublish
SO  - Ther Clin Risk Manag. 2007 Mar;3(1):47-57. doi: 10.2147/tcrm.2007.3.1.47.