PMID- 18360913
OWN - NLM
STAT- MEDLINE
DCOM- 20080513
LR  - 20080402
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 80
IP  - 5
DP  - 2008 May
TI  - Dual infection with hepatitis A and E viruses in outbreaks and in sporadic 
      clinical cases: Cuba 1998-2003.
PG  - 798-802
LID - 10.1002/jmv.21147 [doi]
AB  - Viral hepatitis ranks as the fifth cause of morbidity for infectious diseases in 
      Cuba. Epidemics are observed frequently in the population, the hepatitis A virus 
      being the main agent responsible for such epidemics. Previous reports also 
      confirmed the circulation of the hepatitis E virus. From 1998 to 2003, 258 serum 
      samples were collected by the Reference Laboratory on Viral Hepatitis during 33 
      outbreaks of acute viral hepatitis as well as from 39 sporadic clinical cases. 
      Sera were tested for anti-HAV and anti-HEV IgM by EIA. Overall of the 33 
      outbreaks studied sera from 12 (36.4%) were positive for anti-HAV IgM only, from 
      7 (21.2%) were positive for anti-HEV IgM only, and from 14 (42.4%) were positive 
      for antibodies to both viruses. Individually of the 258 sera collected, 137 
      (53.1%) were positives for anti-HAV IgM, 20 (7.8%) were positives for anti-HEV 
      IgM, 33 (12.8%) were positives for both markers and 68 (26.4%) were negative to 
      both. Of the clinical cases, 4 (10.3%) were positives for anti-HAV IgM, 13 
      (33.3%) were positives for anti-HEV IgM and 5 (12.8%) were positives for both 
      markers. Seventeen (43.6%) sera were negatives for all viral hepatitis markers 
      available (A-E). A high positivity for HEV was found in outbreaks tested with the 
      kit produced by CIGB. In particular HEV seems to infect individuals of all ages. 
      The results demonstrate the co-circulation of and co-infection with two 
      enterically transmitted viruses; however a higher positivity was observed for 
      anti-HAV than to anti-HEV (53.1% vs. 7.8%) in outbreaks.
FAU - Rodriguez Lay, Licel de los Angeles
AU  - Rodriguez Lay Lde L
AD  - Institute for Tropical Medicine Pedro Kouri (IPK), Havana, Cuba. licel@ipk.sld.cu
FAU - Quintana, Ariel
AU  - Quintana A
FAU - Villalba, Maria Caridad Montalvo
AU  - Villalba MC
FAU - Lemos, Gilda
AU  - Lemos G
FAU - Corredor, Marite Bello
AU  - Corredor MB
FAU - Moreno, Aidonis Gutierrez
AU  - Moreno AG
FAU - Prieto, Pablo Aguiar
AU  - Prieto PA
FAU - Guzman, Maria G
AU  - Guzman MG
FAU - Anderson, David
AU  - Anderson D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Hepatitis Antibodies)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Child, Preschool
MH  - Comorbidity
MH  - Cuba/epidemiology
MH  - Disease Outbreaks
MH  - Hepatitis A/*complications/*epidemiology
MH  - Hepatitis Antibodies/blood
MH  - Hepatitis E/*complications/*epidemiology
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin M/blood
MH  - Infant
MH  - Infant, Newborn
MH  - Middle Aged
EDAT- 2008/03/25 09:00
MHDA- 2008/05/14 09:00
CRDT- 2008/03/25 09:00
PHST- 2008/03/25 09:00 [pubmed]
PHST- 2008/05/14 09:00 [medline]
PHST- 2008/03/25 09:00 [entrez]
AID - 10.1002/jmv.21147 [doi]
PST - ppublish
SO  - J Med Virol. 2008 May;80(5):798-802. doi: 10.1002/jmv.21147.