PMID- 18361933
OWN - NLM
STAT- MEDLINE
DCOM- 20080730
LR  - 20111117
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 69
IP  - 2
DP  - 2008 Feb
TI  - Analysis of the binding of gluten T-cell epitopes to various human leukocyte 
      antigen class II molecules.
PG  - 94-100
LID - 10.1016/j.humimm.2008.01.002 [doi]
AB  - Celiac disease is a prevalent disorder of the small intestine that is caused by 
      an inflammatory reaction to dietary gluten in genetically susceptible 
      individuals. More than 90% of patients express the HLA-DQ2 molecule, whereas DQ8 
      is carried by most of the remaining patients. DQ2- and DQ8-mediated presentation 
      of gluten peptides to CD4+ T cells is a key event in the pathogenesis of the 
      disease. The association of celiac disease with these human leukocyte antigen 
      (HLA) molecules is explained by a preferential binding of gluten peptides to 
      these HLA molecules, although the actual data on this in the literature are 
      scarce. The objective of this study was to test this hypothesis. A panel of 
      peptides representing DQ2-restricted gluten T-cell epitopes was tested for 
      binding to various HLA class II molecules using various experimental approaches. 
      The results demonstrate that the gluten T-cell epitopes mainly bind to the DQ2 
      molecule.
FAU - Bergseng, Elin
AU  - Bergseng E
AD  - Centre for Immune Regulation and Institute of Immunology, Rikshospitalet 
      University Hospital, N-0027 Oslo, Norway. elin.bergseng@rr-research.no 
      <elin.bergseng@rr-research.no>
FAU - Sidney, John
AU  - Sidney J
FAU - Sette, Alessandro
AU  - Sette A
FAU - Sollid, Ludvig M
AU  - Sollid LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080208
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (Peptide Fragments)
RN  - 8002-80-0 (Glutens)
SB  - IM
MH  - Antigen Presentation/immunology
MH  - Binding Sites
MH  - Binding, Competitive
MH  - CD4-Positive T-Lymphocytes/*immunology/metabolism
MH  - Celiac Disease/immunology
MH  - Epitopes, T-Lymphocyte/*immunology/metabolism
MH  - Genetic Predisposition to Disease
MH  - Glutens/chemistry/*immunology/metabolism
MH  - HLA-D Antigens/*immunology/metabolism
MH  - HLA-DQ Antigens/immunology/metabolism
MH  - Humans
MH  - Hydrogen Bonding
MH  - Peptide Fragments/chemistry/immunology/metabolism
MH  - Radioligand Assay
EDAT- 2008/03/26 09:00
MHDA- 2008/07/31 09:00
CRDT- 2008/03/26 09:00
PHST- 2007/11/14 00:00 [received]
PHST- 2007/11/24 00:00 [revised]
PHST- 2008/01/10 00:00 [accepted]
PHST- 2008/03/26 09:00 [pubmed]
PHST- 2008/07/31 09:00 [medline]
PHST- 2008/03/26 09:00 [entrez]
AID - S0198-8859(08)00007-4 [pii]
AID - 10.1016/j.humimm.2008.01.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2008 Feb;69(2):94-100. doi: 10.1016/j.humimm.2008.01.002. Epub 2008 
      Feb 8.