PMID- 1836365 OWN - NLM STAT- MEDLINE DCOM- 19920129 LR - 20190516 IS - 0916-7250 (Print) IS - 0916-7250 (Linking) VI - 53 IP - 5 DP - 1991 Oct TI - Changes of plasma concentrations of steroid hormones, prostaglandin F2 alpha-metabolite and pregnant mare serum gonadotropin during pregnancy in thoroughbred mares. PG - 797-801 AB - Plasma concentrations of estrogens, gestagens, cortisol (F), 13, 14-dihydro, 15-keto PGF2 alpha (PGFM) and pregnant mare serum gonadotropin (PMSG) in 10 Thoroughbred mares were measured for a 11-month pregnancy period. Estrone (E1) and estradiol-17 beta (E2) levels gradually increased as the pregnancy advanced, showing a peak around Month 8 and decreased thereafter. Progesterone (P) levels increased on Months 3 and 11, and 17 alpha-OH-progesterone (17 alpha-OHP) levels peaked on Month 3, whereas 20 alpha-OH-progesterone (20 alpha-OHP) levels increased sharply after Month 6. PGFM indicated peaks on Months 2 and 11. F and PMSG levels peaked on Months 2 and 3. From factor analysis, Month, E1, E2 and 20 alpha-OHP were discriminated as Factor 1, increasing with the progress of pregnancy, PMSG, 17 alpha-OHP and P as Factor 2, showing a relation with the secondary corpus luteum, and PGFM and F as Factor 3, affecting PGFM change on Month 2 by F. P also related to both Factors 1 and 3, showing an inverse relation against PGFM. In conclusion E1, E2 and 20 alpha-OHP contained in Factor 1 were suggested to be important especially as parameters of placental function after Month 6. FAU - Tsumagari, S AU - Tsumagari S AD - Department of Veterinary Obstetrics and Gynecology, College of Agriculture and Veterinary Medicine, Nihon University, Kanagawa, Japan. FAU - Higashino, T AU - Higashino T FAU - Takagi, K AU - Takagi K FAU - Ohba, S AU - Ohba S FAU - Satoh, S AU - Satoh S FAU - Takeishi, M AU - Takeishi M LA - eng PT - Journal Article PL - Japan TA - J Vet Med Sci JT - The Journal of veterinary medical science JID - 9105360 RN - 0 (Gonadal Steroid Hormones) RN - 0 (Gonadotropins, Equine) RN - 27376-76-7 (15-keto-13,14-dihydroprostaglandin F2alpha) RN - 2DI9HA706A (Estrone) RN - 4G7DS2Q64Y (Progesterone) RN - 4TI98Z838E (Estradiol) RN - B7IN85G1HY (Dinoprost) RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Animals MH - Dinoprost/*analogs & derivatives/blood MH - Estradiol/blood MH - Estrone/blood MH - Female MH - Gonadal Steroid Hormones/*blood MH - Gonadotropins, Equine/*blood MH - Horses/*blood MH - Hydrocortisone/blood MH - Pregnancy MH - Pregnancy, Animal/*blood MH - Progesterone/blood EDAT- 1991/10/01 00:00 MHDA- 1991/10/01 00:01 CRDT- 1991/10/01 00:00 PHST- 1991/10/01 00:00 [pubmed] PHST- 1991/10/01 00:01 [medline] PHST- 1991/10/01 00:00 [entrez] AID - 10.1292/jvms.53.797 [doi] PST - ppublish SO - J Vet Med Sci. 1991 Oct;53(5):797-801. doi: 10.1292/jvms.53.797.