PMID- 18363853
OWN - NLM
STAT- MEDLINE
DCOM- 20081208
LR  - 20080806
IS  - 1601-183X (Electronic)
IS  - 1601-183X (Linking)
VI  - 7
IP  - 5
DP  - 2008 Jul
TI  - Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice 
      exposed to a restricted feeding schedule.
PG  - 552-9
LID - 10.1111/j.1601-183X.2008.00394.x [doi]
AB  - Increased physical activity and decreased motivation to eat are common features 
      in anorexia nervosa. We investigated the development of these features and the 
      potential implication of brain-derived neurotrophic factor (BDNF) and 
      dopaminergic signalling in their development in C57BL/6J and A/J inbred mice, 
      using the 'activity-based anorexia' model. In this model, mice on a 
      restricted-feeding schedule are given unlimited access to running wheels. We 
      measured dopamine receptor D2 and BDNF expression levels in the caudate putamen 
      and the hippocampus, respectively, using in situ hybridization. We found that in 
      response to scheduled feeding, C57BL/6J mice reduced their running wheel activity 
      and displayed food anticipatory activity prior to food intake from day 2 of 
      scheduled feeding as an indication of motivation to eat. In contrast, A/J mice 
      increased running wheel activity during scheduled feeding and lacked food 
      anticipatory activity. These were accompanied by increased dopamine receptor D2 
      expression in the caudate putamen and reduced BDNF expression in the hippocampus. 
      Consistent with human linkage and association studies on BDNF and dopamine 
      receptor D2 in anorexia nervosa, our study shows that dopaminergic and BDNF 
      signalling are altered as a function of susceptibility to activity-based 
      anorexia. Differences in gene expression and behaviour between A/J and C57BL/6J 
      mice indicate that mouse genetic mapping populations based on these progenitor 
      lines are valuable for identifying molecular determinants of anorexia-related 
      traits.
FAU - Gelegen, C
AU  - Gelegen C
AD  - Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and 
      Pharmacology, Behavioural Genomics Section, University Medical Centre Utrecht, 
      Utrecht, The Netherlands.
FAU - van den Heuvel, J
AU  - van den Heuvel J
FAU - Collier, D A
AU  - Collier DA
FAU - Campbell, I C
AU  - Campbell IC
FAU - Oppelaar, H
AU  - Oppelaar H
FAU - Hessel, E
AU  - Hessel E
FAU - Kas, M J H
AU  - Kas MJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Dopamine D2)
SB  - IM
MH  - Animals
MH  - Anorexia Nervosa/*genetics/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics/*metabolism
MH  - *Caloric Restriction
MH  - Disease Models, Animal
MH  - Female
MH  - Hippocampus/physiology
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Inbred A
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Activity/physiology
MH  - Neostriatum/physiology
MH  - Physical Conditioning, Animal
MH  - RNA, Messenger/metabolism
MH  - Receptors, Dopamine D2/*genetics/*metabolism
MH  - Signal Transduction/physiology
MH  - Species Specificity
EDAT- 2008/03/28 09:00
MHDA- 2008/12/17 09:00
CRDT- 2008/03/28 09:00
PHST- 2008/03/28 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2008/03/28 09:00 [entrez]
AID - GBB394 [pii]
AID - 10.1111/j.1601-183X.2008.00394.x [doi]
PST - ppublish
SO  - Genes Brain Behav. 2008 Jul;7(5):552-9. doi: 10.1111/j.1601-183X.2008.00394.x.