PMID- 18363902
OWN - NLM
STAT- MEDLINE
DCOM- 20081006
LR  - 20211020
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 7
IP  - 3
DP  - 2008 Jun
TI  - Visceral adipose tissue modulates mammalian longevity.
PG  - 438-40
LID - 10.1111/j.1474-9726.2008.00391.x [doi]
AB  - Caloric restriction (CR) can delay many age-related diseases and extend lifespan, 
      while an increase in adiposity is associated with enhanced disease risk and 
      accelerated aging. Among the various fat depots, the accrual of visceral fat (VF) 
      is a common feature of aging, and has been shown to be the most detrimental on 
      metabolic syndrome of aging in humans. We have previously demonstrated that 
      surgical removal of VF in rats improves insulin action; thus, we set out to 
      determine if VF removal affects longevity. We prospectively studied lifespan in 
      three groups of rats: ad libitum-fed (AL-fed), CR (Fed 60% of AL) and a group of 
      AL-fed rats with selective removal of VF at 5 months of age (VF-removed rats). We 
      demonstrate that compared to AL-fed rats, VF-removed rats had a significant 
      increase in mean (p < 0.001) and maximum lifespan (p < 0.04) and significant 
      reduction in the incidence of severe renal disease (p < 0.01). CR rats 
      demonstrated the greatest mean and maximum lifespan (p < 0.001) and the lowest 
      rate of death as compared to AL-fed rats (0.13). Taken together, these 
      observations provide the most direct evidence to date that a reduction in fat 
      mass, specifically VF, may be one of the possible underlying mechanisms of the 
      anti-aging effect of CR.
FAU - Muzumdar, Radhika
AU  - Muzumdar R
AD  - Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New 
      York, NY 10461, USA.
FAU - Allison, David B
AU  - Allison DB
FAU - Huffman, Derek M
AU  - Huffman DM
FAU - Ma, Xiaohui
AU  - Ma X
FAU - Atzmon, Gil
AU  - Atzmon G
FAU - Einstein, Francine H
AU  - Einstein FH
FAU - Fishman, Sigal
AU  - Fishman S
FAU - Poduval, Aruna D
AU  - Poduval AD
FAU - McVei, Theresa
AU  - McVei T
FAU - Keith, Scott W
AU  - Keith SW
FAU - Barzilai, Nir
AU  - Barzilai N
LA  - eng
GR  - K08 AG027462/AG/NIA NIH HHS/United States
GR  - T32 HL079888/HL/NHLBI NIH HHS/United States
GR  - R37 AG018381/AG/NIA NIH HHS/United States
GR  - DK20541/DK/NIDDK NIH HHS/United States
GR  - P30 DK020541/DK/NIDDK NIH HHS/United States
GR  - P60 DK020541/DK/NIDDK NIH HHS/United States
GR  - R01 AG018381/AG/NIA NIH HHS/United States
GR  - K08 AG027462-01A2/AG/NIA NIH HHS/United States
GR  - AG18381/AG/NIA NIH HHS/United States
GR  - P01 AG021654/AG/NIA NIH HHS/United States
GR  - AG21654/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080318
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Intra-Abdominal Fat/*physiology/surgery
MH  - Life Expectancy
MH  - Longevity/*physiology
MH  - Prospective Studies
MH  - Rats
MH  - Thymectomy
PMC - PMC2504027
MID - NIHMS59830
EDAT- 2008/03/28 09:00
MHDA- 2008/10/07 09:00
PMCR- 2008/08/08
CRDT- 2008/03/28 09:00
PHST- 2008/03/28 09:00 [pubmed]
PHST- 2008/10/07 09:00 [medline]
PHST- 2008/03/28 09:00 [entrez]
PHST- 2008/08/08 00:00 [pmc-release]
AID - ACE391 [pii]
AID - 10.1111/j.1474-9726.2008.00391.x [doi]
PST - ppublish
SO  - Aging Cell. 2008 Jun;7(3):438-40. doi: 10.1111/j.1474-9726.2008.00391.x. Epub 
      2008 Mar 18.