PMID- 18367292
OWN - NLM
STAT- MEDLINE
DCOM- 20080507
LR  - 20080421
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 58
IP  - 5
DP  - 2008 May
TI  - Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, 
      and rash/graft-versus-host disease after allogeneic stem cell transplantation.
PG  - 802-9
LID - 10.1016/j.jaad.2008.01.005 [doi]
AB  - BACKGROUND: The relationship between herpesvirus reactivation and 
      graft-versus-host disease (GVHD) after allogeneic stem cell transplantation 
      (allo-SCT) is unclear. OBJECTIVE: We sought to examine the relationship between 
      human herpesvirus (HHV) reactivation and rash/GVHD after allo-SCT by prospective 
      evaluation. METHODS: Fifteen patients who had received allo-SCT underwent 
      prospective serial examinations for human herpesvirus 6 (HHV-6), HHV-7, 
      cytomegalovirus, and Epstein-Barr virus DNA in the blood by polymerase chain 
      reaction and real-time polymerase chain reaction. Serum interferon gamma, 
      interleukins 4 and 10, tumor necrosis factor alpha, and soluble interleukin 2 
      receptor (sIL-2R) were also measured. RESULTS: In 10 of 15 patients, 
      macular/papular eruptions were seen after allo-SCT and GVHD was diagnosed. In 8 
      patients with rash, HHV-6 DNA levels correlated with the cutaneous manifestation. 
      Interleukin 10 and sIL-2R also increased in association with rash. LIMITATIONS: 
      The number of patients in our study was relatively small. Not all patients were 
      examined for cytokines and sIL-2R. CONCLUSIONS: HHV-6 reactivation may be 
      involved in the pathogenesis of rash/GVHD after allo-SCT.
FAU - Kitamura, Kana
AU  - Kitamura K
AD  - Department of Dermatology, Nara Medical University, Nara, Japan.
FAU - Asada, Hideo
AU  - Asada H
FAU - Iida, Hideyuki
AU  - Iida H
FAU - Fukumoto, Takaya
AU  - Fukumoto T
FAU - Kobayashi, Nobuhiko
AU  - Kobayashi N
FAU - Niizeki, Hironori
AU  - Niizeki H
FAU - Morii, Takeshi
AU  - Morii T
FAU - Kimura, Hiroshi
AU  - Kimura H
FAU - Miyagawa, Sachiko
AU  - Miyagawa S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080325
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (DNA, Viral)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Aged
MH  - DNA, Viral/blood
MH  - Exanthema/*etiology
MH  - Female
MH  - Graft vs Host Disease/*etiology/virology
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
MH  - Interleukin-10/*blood
MH  - Male
MH  - Middle Aged
MH  - Stem Cell Transplantation/*adverse effects
MH  - Transplantation, Homologous
MH  - Virus Activation
EDAT- 2008/03/28 09:00
MHDA- 2008/05/08 09:00
CRDT- 2008/03/28 09:00
PHST- 2007/11/13 00:00 [received]
PHST- 2007/12/26 00:00 [revised]
PHST- 2008/01/10 00:00 [accepted]
PHST- 2008/03/28 09:00 [pubmed]
PHST- 2008/05/08 09:00 [medline]
PHST- 2008/03/28 09:00 [entrez]
AID - S0190-9622(08)00125-4 [pii]
AID - 10.1016/j.jaad.2008.01.005 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2008 May;58(5):802-9. doi: 10.1016/j.jaad.2008.01.005. Epub 
      2008 Mar 25.