PMID- 18367429
OWN - NLM
STAT- MEDLINE
DCOM- 20080623
LR  - 20181201
IS  - 1294-9361 (Print)
IS  - 1294-9361 (Linking)
VI  - 10
IP  - 1
DP  - 2008 Mar
TI  - Zonisamide for the treatment of myoclonic seizures in progressive myoclonic 
      epilepsy: an open-label study.
PG  - 31-4
LID - 10.1684/epd.2008.0168 [doi]
AB  - PURPOSE: To examine the safety and efficacy of zonisamide in treating myoclonic 
      seizures associated with progressive myoclonic epilepsy (PME), in an open-label 
      setting. METHODS: Thirty patients with refractory PME (aged > or = 5 years), who 
      were taking up to three antiepileptic drugs, received adjunctive zonisamide (< or 
      = 6 mg/kg/day) therapy for 16 weeks. Myoclonic seizures were recorded daily over 
      a 24-hour period or in 10-minute epochs in the morning, afternoon, and evening. 
      Safety was assessed via adverse events (AEs); efficacy was measured by the 
      percentage of patients experiencing a > or = 50% decrease in myoclonic seizure 
      frequency from baseline. RESULTS: Treatment-related AEs, experienced by 53% (n = 
      16/30) of patients, led to five patients discontinuing zonisamide. The most 
      common AEs were decreased appetite, somnolence, and asthenia. Overall, 36% of 
      patients (n = 10/28) had a > or = 50% reduction in myoclonic seizure frequency. 
      CONCLUSIONS: These results suggest that zonisamide may be useful in the treatment 
      of patients with PME. However, due to the size and open-label character of this 
      study, further research is required.
FAU - Vossler, David G
AU  - Vossler DG
AD  - Epilepsy Center, Washington Neuroscience Institute, Renton, Washington 98055, 
      USA. david_vossler@valleymed.org
FAU - Conry, Joan A
AU  - Conry JA
FAU - Murphy, Jerome V
AU  - Murphy JV
CN  - ZNS-502/505 PME Study Group
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Epileptic Disord
JT  - Epileptic disorders : international epilepsy journal with videotape
JID - 100891853
RN  - 0 (Anticonvulsants)
RN  - 0 (Isoxazoles)
RN  - 459384H98V (Zonisamide)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/adverse effects/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Isoxazoles/adverse effects/*therapeutic use
MH  - Male
MH  - Myoclonic Epilepsies, Progressive/*drug therapy
MH  - Seizures/drug therapy
MH  - Zonisamide
FIR - Boustany, Rose-Mary
IR  - Boustany RM
FIR - Legarda, Stella
IR  - Legarda S
FIR - Ruggles, Kevin
IR  - Ruggles K
FIR - Schachter, Steven
IR  - Schachter S
FIR - Kaackuzhali, Krishnamurthy
IR  - Kaackuzhali K
FIR - Sheth, Raj
IR  - Sheth R
FIR - Vasquez, Blanca
IR  - Vasquez B
FIR - Barkley, Greg
IR  - Barkley G
FIR - Chugani, Harry
IR  - Chugani H
FIR - Flamini, Robert
IR  - Flamini R
FIR - Sirven, Joseph
IR  - Sirven J
FIR - Uthman, Basim
IR  - Uthman B
FIR - Wheless, James
IR  - Wheless J
FIR - Asconape, Jorge
IR  - Asconape J
FIR - Miller, G Steve
IR  - Miller GS
FIR - Pellock, John
IR  - Pellock J
FIR - Van Orman, Colin
IR  - Van Orman C
EDAT- 2008/03/28 09:00
MHDA- 2008/06/24 09:00
CRDT- 2008/03/28 09:00
PHST- 2007/07/18 00:00 [received]
PHST- 2007/12/26 00:00 [accepted]
PHST- 2008/03/28 09:00 [pubmed]
PHST- 2008/06/24 09:00 [medline]
PHST- 2008/03/28 09:00 [entrez]
AID - epd.2008.0168 [pii]
AID - 10.1684/epd.2008.0168 [doi]
PST - ppublish
SO  - Epileptic Disord. 2008 Mar;10(1):31-4. doi: 10.1684/epd.2008.0168.