PMID- 18367833
OWN - NLM
STAT- MEDLINE
DCOM- 20080728
LR  - 20221207
IS  - 1421-9670 (Electronic)
IS  - 0250-8095 (Print)
IS  - 0250-8095 (Linking)
VI  - 28
IP  - 4
DP  - 2008
TI  - Human leukocyte antigen DRB1 alleles predict risk and disease progression of 
      immunoglobulin A nephropathy in Han Chinese.
PG  - 684-91
LID - 10.1159/000122111 [doi]
AB  - The role of human leukocyte antigen (HLA) class II polymorphisms in the 
      pathogenesis and progression of primary immunoglobulin A nephropathy (pIgAN) is 
      unclear. This study aimed to explore the relationship of HLA-DRB1 alleles with 
      the susceptibility and disease progression of pIgAN in Han Chinese. A PCR-based 
      genotyping technique was used to detect HLA-DRB1 alleles in 139 patients with 
      pIgAN and 143 healthy subjects. A total of 37 HLA-DRB1 alleles were detected, of 
      which 30 were found in pIgAN patients and 29 in healthy subjects. In pIgAN 
      patients, the frequencies of HLA-DRB1*140501 (belonging to DR*14) were 
      significantly increased, while the frequencies of HLA-DRB1*070101 (belonging to 
      DR*7) were significantly reduced compared with the healthy individuals. Further 
      stratification analysis revealed that the frequencies of HLA-DRB1*030101 in pIgAN 
      patients with normal renal function were significantly higher than those in 
      patients with renal dysfunction. These findings suggest that HLA-DRB1 
      polymorphisms are related to the occurrence and disease progression of pIgAN 
      patients in Han Chinese, with HLA-DRB1*140501 being a susceptible allele and 
      HLA-DRB1*070101 a resistant allele. HLA-DRB1*030101 may serve as a predictor of 
      disease progression and renal damage of pIgAN in Han Chinese. Further studies are 
      warranted to explore the immunological mechanisms for the genotype-disease 
      phenotype relationship.
CI  - Copyright 2008 S. Karger AG, Basel.
FAU - Cao, Hui-Xia
AU  - Cao HX
AD  - Department of Nephropathy, The First Affiliated Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Li, Ming
AU  - Li M
FAU - Nie, Jing
AU  - Nie J
FAU - Wang, Wie
AU  - Wang W
FAU - Zhou, Shu-Feng
AU  - Zhou SF
FAU - Yu, Xue-Qing
AU  - Yu XQ
LA  - eng
PT  - Journal Article
DEP - 20080326
PL  - Switzerland
TA  - Am J Nephrol
JT  - American journal of nephrology
JID - 8109361
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - China
MH  - Disease Progression
MH  - Disease Susceptibility
MH  - Female
MH  - Glomerulonephritis, IGA/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Human Growth Hormone
MH  - Humans
MH  - Male
PMC - PMC2786014
EDAT- 2008/03/28 09:00
MHDA- 2008/07/29 09:00
PMCR- 2008/03/26
CRDT- 2008/03/28 09:00
PHST- 2007/11/06 00:00 [received]
PHST- 2008/02/18 00:00 [accepted]
PHST- 2008/03/28 09:00 [pubmed]
PHST- 2008/07/29 09:00 [medline]
PHST- 2008/03/28 09:00 [entrez]
PHST- 2008/03/26 00:00 [pmc-release]
AID - 000122111 [pii]
AID - ajn0028-0684 [pii]
AID - 10.1159/000122111 [doi]
PST - ppublish
SO  - Am J Nephrol. 2008;28(4):684-91. doi: 10.1159/000122111. Epub 2008 Mar 26.