PMID- 18370147
OWN - NLM
STAT- MEDLINE
DCOM- 20080619
LR  - 20240105
IS  - 1064-3745 (Print)
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 415
DP  - 2008
TI  - KIR locus polymorphisms: genotyping and disease association analysis.
PG  - 49-64
LID - 10.1007/978-1-59745-570-1_3 [doi]
AB  - The genes encoding the killer immunoglobulin-like receptors (KIR) are situated 
      within a segment of DNA that has undergone expansion and contraction over time 
      due in large part to unequal crossing over. Consequently, individuals exhibit 
      considerable haplotypic variation in terms of gene content. The highly 
      polymorphic human leukocyte antigen (HLA) class I loci encode ligands for the 
      KIR; thus, it is not surprising that KIR genes also show significant allelic 
      polymorphism. As a result of the receptor-ligand relationship between KIR and 
      HLA, functionally relevant KIR-HLA combinations need to be considered in the 
      analysis of these genes as they relate to disease outcomes. This chapter will 
      describe a genotyping method for identifying the presence/absence of the KIR 
      genes and general approaches to data analysis in disease association studies.
FAU - Martin, Maureen P
AU  - Martin MP
AD  - Laboratory of Genomic Diversity, SAIC-Frederick, Inc., NCI-Frederick, Frederick, 
      MD, USA.
FAU - Carrington, Mary
AU  - Carrington M
LA  - eng
GR  - N01CO12400/CA/NCI NIH HHS/United States
GR  - Z01 BC010791/ImNIH/Intramural NIH HHS/United States
GR  - N01-CO-12400/CO/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (KIR2DS4 protein, human)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Arthritis, Psoriatic/genetics
MH  - Electrophoresis, Agar Gel
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Receptors, KIR/*genetics
PMC - PMC10763752
MID - NIHMS1949004
EDAT- 2008/03/29 09:00
MHDA- 2008/06/20 09:00
PMCR- 2024/01/03
CRDT- 2008/03/29 09:00
PHST- 2008/03/29 09:00 [pubmed]
PHST- 2008/06/20 09:00 [medline]
PHST- 2008/03/29 09:00 [entrez]
PHST- 2024/01/03 00:00 [pmc-release]
AID - 10.1007/978-1-59745-570-1_3 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2008;415:49-64. doi: 10.1007/978-1-59745-570-1_3.