PMID- 18370160
OWN - NLM
STAT- MEDLINE
DCOM- 20080619
LR  - 20080328
IS  - 1064-3745 (Print)
IS  - 1064-3745 (Linking)
VI  - 415
DP  - 2008
TI  - Clinical analysis of dendritic cell subsets: the dendritogram.
PG  - 273-90
LID - 10.1007/978-1-59745-570-1_16 [doi]
AB  - Dendritic cells (DCs) are crucial in adaptive immunity because they are the only 
      antigen-presenting cells that can present antigens to naive T lymphocytes. 
      Plasmacytoid DCs (pDC) are also the main producers of type I Interferons in 
      response to infection. We have shown that circulating myeloid DC (mDC) and pDC 
      numbers are reduced in chronic as well as primary HIV infection. Data from 
      different laboratories indicate that pDC counts, obtained by flow cytometry and 
      rare event analysis, correlate inversely with the viral load, may be an early 
      marker of recovery after antiretroviral treatment, and may predict better immune 
      control of HIV replication. PDC counts may also be predictive of severe illness 
      in dengue virus infection or of successful treatment against Mycobacterium 
      tuberculosis. DC counts, or the "dendritogram", may therefore become useful in 
      the clinical assessment of different infectious diseases.
FAU - Hosmalin, Anne
AU  - Hosmalin A
AD  - Institut Cochin, Departement d'Immunologie, Paris, France.
FAU - Lichtner, Miriam
AU  - Lichtner M
FAU - Louis, Stephanie
AU  - Louis S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
RN  - 0 (Antibodies)
SB  - IM
MH  - Animals
MH  - Antibodies
MH  - Biological Assay
MH  - Blood Cell Count
MH  - Cell Separation
MH  - Dendritic Cells/*cytology
MH  - Immunohistochemistry/*methods
MH  - Leukocytes, Mononuclear/cytology
EDAT- 2008/03/29 09:00
MHDA- 2008/06/20 09:00
CRDT- 2008/03/29 09:00
PHST- 2008/03/29 09:00 [pubmed]
PHST- 2008/06/20 09:00 [medline]
PHST- 2008/03/29 09:00 [entrez]
AID - 10.1007/978-1-59745-570-1_16 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2008;415:273-90. doi: 10.1007/978-1-59745-570-1_16.