PMID- 18371186
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20220330
IS  - 1015-6305 (Print)
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Linking)
VI  - 18
IP  - 3
DP  - 2008 Jul
TI  - Comprehensive characterization of genomic aberrations in gangliogliomas by CGH, 
      array-based CGH and interphase FISH.
PG  - 326-37
LID - 10.1111/j.1750-3639.2008.00122.x [doi]
AB  - Gangliogliomas are generally benign neuroepithelial tumors composed of dysplastic 
      neuronal and neoplastic glial elements. We screened 61 gangliogliomas [World 
      Health Organization (WHO) grade I] for genomic alterations by chromosomal and 
      array-based comparative genomic hybridization (CGH). Aberrations were detected in 
      66% of gangliogliomas (mean +/- SEM = 2.5 +/- 0.5 alterations/tumor). Frequent 
      gains were on chromosomes 7 (21%), 5 (16%), 8 (13%), 12 (12%); frequent losses on 
      22q (16%), 9 (10%), 10 (8%). Recurrent partial imbalances comprised the minimal 
      overlapping regions dim(10)(q25) and enh(12)(q13.3-q14.1). Unsupervised cluster 
      analysis of genomic profiles detected two major subgroups (group I: complete gain 
      of 7 and additional gains of 5, 8 or 12; group II: no major recurring imbalances, 
      mainly losses). A comparison with low-grade gliomas (astrocytomas WHO grade II) 
      showed chromosome 5 gain to be significantly more frequent in gangliogliomas. 
      Interphase fluorescence in situ hybridization (FISH) identified the aberrations 
      to be contained in a subpopulation of glial but not in neuronal cells. Two 
      gangliogliomas and their anaplastic recurrences (WHO grade III) were analyzed. 
      Losses of CDKN2A/B and DMBT1 or a gain/amplification of CDK4 found in the 
      anaplastic tumors were already present in the respective gangliogliomas by array 
      CGH and interphase FISH. In summary, genomic profiling in a large series of 
      gangliogliomas could distinguish genetic subgroups even in this low-grade tumor.
FAU - Hoischen, Alexander
AU  - Hoischen A
AD  - Department of Human Genetics, Rheinische Friedrich-Wilhelms-University of Zurich, 
      Zurich, Switerland.
FAU - Ehrler, Marion
AU  - Ehrler M
FAU - Fassunke, Jana
AU  - Fassunke J
FAU - Simon, Matthias
AU  - Simon M
FAU - Baudis, Michael
AU  - Baudis M
FAU - Landwehr, Christina
AU  - Landwehr C
FAU - Radlwimmer, Bernhard
AU  - Radlwimmer B
FAU - Lichter, Peter
AU  - Lichter P
FAU - Schramm, Johannes
AU  - Schramm J
FAU - Becker, Albert J
AU  - Becker AJ
FAU - Weber, Ruthild G
AU  - Weber RG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080326
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain Neoplasms/*genetics
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - Cytogenetic Analysis
MH  - Female
MH  - Ganglioglioma/*genetics
MH  - Gene Expression Profiling
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nucleic Acid Hybridization
PMC - PMC8095656
EDAT- 2008/03/29 09:00
MHDA- 2008/08/30 09:00
PMCR- 2008/03/27
CRDT- 2008/03/29 09:00
PHST- 2008/03/29 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/03/29 09:00 [entrez]
PHST- 2008/03/27 00:00 [pmc-release]
AID - BPA122 [pii]
AID - 10.1111/j.1750-3639.2008.00122.x [doi]
PST - ppublish
SO  - Brain Pathol. 2008 Jul;18(3):326-37. doi: 10.1111/j.1750-3639.2008.00122.x. Epub 
      2008 Mar 26.