PMID- 18373066
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20211020
IS  - 0167-594X (Print)
IS  - 0167-594X (Linking)
VI  - 88
IP  - 3
DP  - 2008 Jul
TI  - Two metachronous tumors induced by radiation therapy: case report and review of 
      the literature.
PG  - 315-20
LID - 10.1007/s11060-008-9570-0 [doi]
AB  - Various radiation-induced tumors, including meningioma, glioma, and sarcoma, have 
      been reported; however, metachronous intracranial double tumors induced by 
      radiation therapy are extremely rare. A 1-year-old boy had undergone tumor 
      removal and craniospinal radiation therapy (30 Gy) for cerebellar 
      medulloblastoma. At 24 years old, parasagittal meningioma developed in the left 
      parietal region and was totally removed. Six years later, an infiltrative tumor 
      was newly found in the right fronto-temporal white matter. The patient underwent 
      stereotactic biopsy, and the tumor was found to be an anaplastic astrocytoma. 
      Chromosomal analysis by fluorescence in situ hybridization (FISH) revealed loss 
      of heterozygosity (LOH) of 1p. As the patient had previously had craniospinal 
      irradiation, no additional radiation therapy was delivered. He underwent 
      chemotherapy with temozolomide and the disease is now stable. Since both 
      secondary tumors were located within the area of previous radiation and the 
      patient did not have any genetic disease predisposing him to tumors, radiation 
      therapy was considered to be responsible for their tumorigenesis. To our 
      knowledge, this case is the fourth case of radiation-induced double CNS tumors 
      arising after radiotherapy to be described in the literature. Whenever radiation 
      is administered to children or young adults, careful serial screening studies are 
      needed.
FAU - Sasayama, Takashi
AU  - Sasayama T
AD  - Department of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-1 
      Kusunoki-cho, Chuo-ku, Kobe, Japan. takasasa@med.kobe-u.ac.jp
FAU - Nishihara, Masamitsu
AU  - Nishihara M
FAU - Tanaka, Kazuhiro
AU  - Tanaka K
FAU - Mizukawa, Katsu
AU  - Mizukawa K
FAU - Ehara, Kazumasa
AU  - Ehara K
FAU - Kanomata, Naoki
AU  - Kanomata N
FAU - Kohmura, Eiji
AU  - Kohmura E
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20080329
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Astrocytoma/etiology/genetics/*pathology
MH  - Brain Neoplasms/etiology/genetics/*pathology
MH  - Cerebellar Neoplasms/radiotherapy
MH  - Cranial Irradiation/adverse effects
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Loss of Heterozygosity
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Medulloblastoma/radiotherapy
MH  - Meningeal Neoplasms/etiology/*pathology
MH  - Meningioma/etiology/*pathology
MH  - Neoplasms, Radiation-Induced/*pathology
MH  - Neoplasms, Second Primary/etiology/*pathology
EDAT- 2008/04/01 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/04/01 09:00
PHST- 2008/01/09 00:00 [received]
PHST- 2008/03/17 00:00 [accepted]
PHST- 2008/04/01 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/04/01 09:00 [entrez]
AID - 10.1007/s11060-008-9570-0 [doi]
PST - ppublish
SO  - J Neurooncol. 2008 Jul;88(3):315-20. doi: 10.1007/s11060-008-9570-0. Epub 2008 
      Mar 29.