PMID- 18373321
OWN - NLM
STAT- MEDLINE
DCOM- 20080722
LR  - 20191027
IS  - 0391-3988 (Print)
IS  - 0391-3988 (Linking)
VI  - 31
IP  - 3
DP  - 2008 Mar
TI  - Disturbed cerebral circulation during opening of the venoarterial bypass bridge 
      in extracorporeal membrane oxygenation.
PG  - 266-71
AB  - PURPOSE: To describe the effects on cerebral blood flow velocity (CBFV) of 
      intermittent opening of the venoarterial bridge (VA bridge) during venoarterial 
      extracorporeal membrane oxygenation (VA-ECMO). STUDY DESIGN: Prospective study in 
      22 newborns during VA ECMO. CBFV was measured in the pericallosal artery by 
      Doppler ultrasound. Changes in peak systolic flow velocity (PSV), end diastolic 
      flow velocity (EDV) and time-averaged mean flow velocity (TAM) on day 1, 2, 3, 
      and 5 and at low ECMO flow (50- 150 ml/min) were analyzed (mean 
      percentage+/-standard deviation (t-tests, p<0.05)). Changes >25% were considered 
      relevant. The relationship between changes in CBFV and ECMO flow rate (Pearson 
      correlation, p<0.01) was studied. RESULTS: Opening of the VA bridge resulted in 
      statistically significant and relevant decreases in PSV (35 +/- 18%), EDV (93 +/- 
      15%) and TAM (68 +/- 13%), persisting during the consecutive days of treatment. 
      Smaller changes in CBFV at low ECMO flow were statistically significant and 
      mostly relevant: PSV (15 +/- 7%), EDV (76 +/- 21%) and TAM (40 +/- 12%). Changes 
      in CBFV were positively correlated to the ECMO flow. CONCLUSION: Use of the VA 
      bridge results in significant and relevant ECMO flow-dependent changes in CBFV, 
      persisting during the treatment. The VA bridge should be used in such a way as to 
      allow regular unclamping to be omitted.
FAU - De Mol, A C
AU  - De Mol AC
AD  - Department of Pediatrics, Neonatology, Radboud University Nijmegen Medical 
      Center, Nijmegen, The Netherlands. a.c.demol@cukz.umcn.nl
FAU - Van Heijst, A F
AU  - Van Heijst AF
FAU - Van der Staak, F H
AU  - Van der Staak FH
FAU - Liem, K D
AU  - Liem KD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Artif Organs
JT  - The International journal of artificial organs
JID - 7802649
SB  - IM
MH  - Blood Flow Velocity
MH  - Cerebral Hemorrhage/prevention & control
MH  - *Cerebrovascular Circulation/physiology
MH  - Extracorporeal Membrane Oxygenation/*methods
MH  - Humans
MH  - Infant, Newborn
MH  - Prospective Studies
MH  - Ultrasonography, Doppler
EDAT- 2008/04/01 09:00
MHDA- 2008/07/23 09:00
CRDT- 2008/04/01 09:00
PHST- 2008/04/01 09:00 [pubmed]
PHST- 2008/07/23 09:00 [medline]
PHST- 2008/04/01 09:00 [entrez]
AID - 10.1177/039139880803100311 [doi]
PST - ppublish
SO  - Int J Artif Organs. 2008 Mar;31(3):266-71. doi: 10.1177/039139880803100311.