PMID- 18374602
OWN - NLM
STAT- MEDLINE
DCOM- 20080709
LR  - 20211027
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 41
IP  - 1
DP  - 2008 May 15
TI  - Putaminal activity is related to perceptual certainty.
PG  - 123-9
LID - 10.1016/j.neuroimage.2008.01.034 [doi]
AB  - We have investigated the neural basis of perceptual certainty using a simple 
      discrimination paradigm. Psychophysical experiments have shown that a pair of 
      identical electrical stimuli to the skin or a pair of auditory clicks to the ears 
      are consistently perceived as two separate events in time when the inter-stimulus 
      interval (ISIs) is long, and perceived as simultaneous events when the ISIs are 
      very short. The perceptual certainty of having received one or two stimuli 
      decreases when the ISI lies between these two extremes and this is reflected in 
      inconsistent reporting of the percept across trials. In two fMRI experiments, 14 
      healthy subjects received either paired electrical pulses delivered to the 
      forearm (ISIs=5-110 ms) or paired auditory clicks presented binaurally (ISIs=1-20 
      ms). For each subject and modality, we calculated a consistency index (CI) 
      representing the level of perceptual certainty. The task activated pre-SMA and 
      anterior cingulate cortex, plus the cerebellum and the basal ganglia. Critically, 
      activity in the right putamen was linearly dependent on CI for both tactile and 
      auditory discrimination, with topographically distinct effects in the two 
      modalities. These results support a role for the human putamen in the "automatic" 
      perception of temporal features of tactile and auditory stimuli.
FAU - Pastor, M A
AU  - Pastor MA
AD  - Department of the Neurosciences, Center for Applied Medical Research, University 
      of Navarra School of Medicine, Pamplona, Spain. mapastor@unav.es
FAU - Macaluso, E
AU  - Macaluso E
FAU - Day, B L
AU  - Day BL
FAU - Frackowiak, R S J
AU  - Frackowiak RS
LA  - eng
GR  - G0501740/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080201
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Auditory Perception/physiology
MH  - Auditory Threshold/physiology
MH  - Basal Ganglia/physiology
MH  - Discrimination, Psychological/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Perception/*physiology
MH  - Physical Stimulation
MH  - Psychomotor Performance/physiology
MH  - Putamen/*physiology
MH  - Sensory Thresholds/physiology
MH  - Touch/physiology
EDAT- 2008/04/01 09:00
MHDA- 2008/07/10 09:00
CRDT- 2008/04/01 09:00
PHST- 2007/04/11 00:00 [received]
PHST- 2008/01/15 00:00 [revised]
PHST- 2008/01/20 00:00 [accepted]
PHST- 2008/04/01 09:00 [pubmed]
PHST- 2008/07/10 09:00 [medline]
PHST- 2008/04/01 09:00 [entrez]
AID - S1053-8119(08)00093-1 [pii]
AID - 10.1016/j.neuroimage.2008.01.034 [doi]
PST - ppublish
SO  - Neuroimage. 2008 May 15;41(1):123-9. doi: 10.1016/j.neuroimage.2008.01.034. Epub 
      2008 Feb 1.