PMID- 18374880
OWN - NLM
STAT- MEDLINE
DCOM- 20080429
LR  - 20080331
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 27
IP  - 4
DP  - 2008 Apr
TI  - Sex-specific predictive power of 6-minute walk test in chronic heart failure is 
      not enhanced using percent achieved of published reference equations.
PG  - 427-34
LID - 10.1016/j.healun.2008.01.010 [doi]
AB  - BACKGROUND: The 6-minute walk test (6MWT) is an established prognostic tool in 
      chronic heart failure. The strong influence of height, weight, age, and sex on 
      6MWT distance may be accounted for by using percentage achieved of predicted 
      value rather than uncorrected 6MWT values. METHODS: The study included 1069 
      patients (862 men) with a mean age 55.2 +/- 11.7 years and mean left ventricular 
      ejection fraction of 29% +/- 10%, attending the heart failure clinic of the 
      University of Heidelberg between 1995 and 2005. The predictive power and accuracy 
      of 6MWT and achieved percentage values according to all available published 
      equations for mortality and mortality or transplant combined were tested 
      separately for each sex. RESULTS: The percentage values varied largely between 
      equations. For all equations, women in New York Heart Association (NYHA) 
      functional class I had higher values than men. Although the 6MWT significantly 
      discriminated all NYHA classes for both sexes, only 1 equation discriminated all 
      NYHA classes. No significant differences in the area under the receiver 
      operating-characteristic curve were noted between achieved percentage values and 
      6MWT. Despite strong univariate significance, achieved percentage values did not 
      retain multivariate significance. The 6MWT was independent from N-terminal brain 
      natriuretic propeptide, NYHA, left ventricular ejection fraction, and peak oxygen 
      uptake. CONCLUSION: We confirmed 6MWT to be a strong and independent risk 
      predictor for both sexes. Because the prognostic power of 6MWT is not enhanced 
      using percentage achieved of published reference equations, we suggest 
      recalibration of these reference values rather than discarding this approach.
FAU - Frankenstein, Lutz
AU  - Frankenstein L
AD  - Department of Cardiology, Angiology, and Pneumology, University of Heidelberg, 
      Heidelberg, Germany. Luts.Frankenstein@med.uni-heidelberg.de
FAU - Zugck, Christian
AU  - Zugck C
FAU - Nelles, Manfred
AU  - Nelles M
FAU - Schellberg, Dieter
AU  - Schellberg D
FAU - Katus, Hugo
AU  - Katus H
FAU - Remppis, Andrew
AU  - Remppis A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Cardiovascular
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - ROC Curve
MH  - Reference Values
MH  - Risk Assessment
MH  - *Sex Factors
MH  - Time Factors
MH  - *Walking
EDAT- 2008/04/01 09:00
MHDA- 2008/04/30 09:00
CRDT- 2008/04/01 09:00
PHST- 2007/09/13 00:00 [received]
PHST- 2007/12/02 00:00 [revised]
PHST- 2008/01/08 00:00 [accepted]
PHST- 2008/04/01 09:00 [pubmed]
PHST- 2008/04/30 09:00 [medline]
PHST- 2008/04/01 09:00 [entrez]
AID - S1053-2498(08)00038-7 [pii]
AID - 10.1016/j.healun.2008.01.010 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2008 Apr;27(4):427-34. doi: 
      10.1016/j.healun.2008.01.010.