PMID- 18375961
OWN - NLM
STAT- MEDLINE
DCOM- 20080801
LR  - 20211020
IS  - 1460-2180 (Electronic)
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 29
IP  - 5
DP  - 2008 May
TI  - Polymorphism of genes related to insulin sensitivity and the risk of biliary 
      tract cancer and biliary stone: a population-based case-control study in 
      Shanghai, China.
PG  - 944-8
LID - 10.1093/carcin/bgn025 [doi]
AB  - Biliary tract cancer, encompassing tumors of the gallbladder, extrahepatic bile 
      ducts and ampulla of Vater, is a rare but highly fatal malignancy. Obesity and 
      gallstones, both related to insulin resistance, are linked to an elevated risk of 
      biliary cancer. The peroxisome proliferator-activated receptors (PPARs) and the 
      retinoid X receptors (RXRs), expressed in adipose tissue, play a key role in the 
      regulation of obesity-related insulin sensitivity, thus genetic variants of these 
      two receptor genes may be related to biliary cancer and stones. We examined the 
      associations of seven single-nucleotide polymorphisms in the PPAR-gamma, 
      PPAR-delta, RXR-alpha, RXR-beta and INS genes with biliary cancer and stones in a 
      population-based case-control study in Shanghai, China. We included 237 
      gallbladder, 127 extrahepatic bile duct and 47 ampulla of Vater cancer cases, 895 
      stone cases and 786 population controls. Relative to individuals with the 
      RXR-beta C51T (rs2076310) CC genotype, those having the TT genotype had a 
      1.6-fold risk for bile duct cancer [odds ratio (OR) = 1.67; 95% confidence 
      interval (CI) = 0.99-2.84], with a more pronounced association among men (OR = 
      2.30; 95% CI = 1.14-4.65; P interaction = 0.07). This marker was also associated 
      with a higher risk of gallstones among subjects with a higher body mass index 
      (BMI) (>or=23 kg/m(2)) (OR = 1.80; 95% CI = 1.09-2.94), although the interaction 
      with BMI was not statistically significant (P interaction = 0.28). No association 
      was found between other variants and biliary cancers and stones. Results from 
      this population-based study suggest that certain genetic variants involved in the 
      regulation of obesity-related insulin sensitivity may increase susceptibility to 
      bile duct cancer and gallstones.
FAU - Chang, Shih-Chen
AU  - Chang SC
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National 
      Institutes of Health, DHHS, Bethesda, MD 20892, USA.
FAU - Rashid, Asif
AU  - Rashid A
FAU - Gao, Yu-Tang
AU  - Gao YT
FAU - Andreotti, Gabriella
AU  - Andreotti G
FAU - Shen, Ming-Chang
AU  - Shen MC
FAU - Wang, Bin-Sheng
AU  - Wang BS
FAU - Han, Tian-Quan
AU  - Han TQ
FAU - Zhang, Bai-He
AU  - Zhang BH
FAU - Sakoda, Lori C
AU  - Sakoda LC
FAU - Leitzmann, Michael F
AU  - Leitzmann MF
FAU - Chen, Bingshu E
AU  - Chen BE
FAU - Rosenberg, Philip S
AU  - Rosenberg PS
FAU - Chen, Jinbo
AU  - Chen J
FAU - Chanock, Stephen J
AU  - Chanock SJ
FAU - Hsing, Ann W
AU  - Hsing AW
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20080328
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Insulin)
RN  - 0 (PPAR gamma)
RN  - 0 (RARA protein, human)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 0 (retinoic acid receptor beta)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bile Duct Neoplasms/epidemiology/genetics
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - DNA, Neoplasm/genetics/isolation & purification
MH  - Female
MH  - Gallbladder Neoplasms/*epidemiology/*genetics
MH  - Gallstones/*epidemiology/*genetics
MH  - Humans
MH  - Incidence
MH  - Insulin/*genetics
MH  - Interviews as Topic
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - PPAR gamma/genetics
MH  - *Polymorphism, Genetic
MH  - Receptors, Retinoic Acid/genetics
MH  - Retinoic Acid Receptor alpha
MH  - Risk Factors
PMC - PMC2443392
EDAT- 2008/04/01 09:00
MHDA- 2008/08/02 09:00
PMCR- 2008/03/28
CRDT- 2008/04/01 09:00
PHST- 2008/04/01 09:00 [pubmed]
PHST- 2008/08/02 09:00 [medline]
PHST- 2008/04/01 09:00 [entrez]
PHST- 2008/03/28 00:00 [pmc-release]
AID - bgn025 [pii]
AID - 10.1093/carcin/bgn025 [doi]
PST - ppublish
SO  - Carcinogenesis. 2008 May;29(5):944-8. doi: 10.1093/carcin/bgn025. Epub 2008 Mar 
      28.