PMID- 18379218 OWN - NLM STAT- MEDLINE DCOM- 20080522 LR - 20221207 IS - 0195-9131 (Print) IS - 0195-9131 (Linking) VI - 40 IP - 3 DP - 2008 Mar TI - BDNF, metabolic risk factors, and resistance training in middle-aged individuals. PG - 535-41 LID - 10.1249/MSS.0b013e31815dd057 [doi] AB - INTRODUCTION AND PURPOSE: Brain-derived neurotrophic factor (BDNF) and physical inactivity contribute to the development of the metabolic syndrome (MetS). There appears to be an association between BDNF and risk factors for MetS, and the effects of resistance training (RT) on BDNF and metabolic risk in middle-aged individuals with high and low numbers of metabolic risk factors (HiMF and LoMF, respectively) are unclear and are the focus of this research. METHODS: Forty-nine men (N = 25) and women (N = 24) aged 50.9 +/- 6.2 yr were randomized to four groups, HiMF training (HiMFT), HiMF control (HiMFC), LoMF training (LoMFT), and LoMF control (LoMFC). Before and after 10 wk of RT, participants underwent tests for muscle strength and anthropometry, and a fasting blood sample was taken. Data were analyzed using Spearman correlations and repeated-measures ANOVA. RESULTS: BDNF was positively correlated with plasma triglycerides, glucose, HbA1C, and insulin resistance. BDNF was elevated in HiMF compared with LoMF (904.9 +/- 270.6 vs 709.6 +/- 239.8 respectively, P = 0.01). Training increased muscle strength and lean body mass but had no effect on BDNF levels or any examined risk factors. CONCLUSION: BDNF levels correlated with risk factors for MetS and were elevated in individuals with HiMF. RT had no effect on BDNF levels or other risk factors for MetS. As RT has an effect on muscle strength and lean body mass, it should be added to other nonpharmacological interventions for middle-aged individuals with HiMF such as aerobic and/or diet. FAU - Levinger, Itamar AU - Levinger I AD - School of Human Movement, Recreation and Performance, Victoria University, Melbourne, Australia. itamar.levinger@research.vu.edu.au FAU - Goodman, Craig AU - Goodman C FAU - Matthews, Vance AU - Matthews V FAU - Hare, David L AU - Hare DL FAU - Jerums, George AU - Jerums G FAU - Garnham, Andrew AU - Garnham A FAU - Selig, Steve AU - Selig S LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Med Sci Sports Exerc JT - Medicine and science in sports and exercise JID - 8005433 RN - 0 (Blood Glucose) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Glycated Hemoglobin A) RN - 0 (Triglycerides) SB - IM MH - Adult MH - Anthropometry MH - Blood Glucose/analysis MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Female MH - Glycated Hemoglobin/analysis MH - Humans MH - Insulin Resistance MH - Male MH - Metabolic Syndrome/*etiology/physiopathology MH - Middle Aged MH - Muscle Strength MH - Risk Factors MH - Triglycerides/blood MH - Victoria MH - Weight Lifting/*physiology EDAT- 2008/04/02 09:00 MHDA- 2008/05/23 09:00 CRDT- 2008/04/02 09:00 PHST- 2008/04/02 09:00 [pubmed] PHST- 2008/05/23 09:00 [medline] PHST- 2008/04/02 09:00 [entrez] AID - 10.1249/MSS.0b013e31815dd057 [doi] PST - ppublish SO - Med Sci Sports Exerc. 2008 Mar;40(3):535-41. doi: 10.1249/MSS.0b013e31815dd057.