PMID- 18379420
OWN - NLM
STAT- MEDLINE
DCOM- 20080731
LR  - 20080417
IS  - 1044-3983 (Print)
IS  - 1044-3983 (Linking)
VI  - 19
IP  - 3
DP  - 2008 May
TI  - A structural approach to the familial coaggregation of disorders.
PG  - 431-9
LID - 10.1097/EDE.0b013e31816a9de7 [doi]
AB  - The demonstration that 2 disorders coaggregate in families is often the first 
      step in the exploration of genetic factors common to the 2 disorders. Previous 
      methods of analyzing familial coaggregation have used either (1) a typical 
      measure of association (eg, the odds ratio) between a disorder in an individual 
      and another disorder in family members, or (2) a linear structural equation model 
      (SEM). The association method accommodates case-control sampling of families, but 
      may not assess the causal effect of interest because it is not based on an 
      underlying causal model. The SEM method is based on a causal model, but cannot 
      easily accommodate case-control sampling or direct effects of 1 disorder on the 
      other within individuals. We develop a new method of analyzing coaggregation 
      based on directed acyclic graphs. Because this method is a generalization of 
      structural equation models and uses measures of association that accommodate 
      case-control sampling and direct effects, it combines the strengths of both 
      previous methods. In the absence of direct effects between disorders, our 
      approach provides a valid estimate of the causal coaggregation effect. In the 
      presence of direct effects, our approach provides an upper-bound estimate and 
      (assuming additive linear effects of latent familial and nonfamilial factors) a 
      lower-bound estimate of the causal coaggregation effect. For illustration, we 
      applied our method to a family study of binge eating disorder and bipolar 
      disorder.
FAU - Hudson, James I
AU  - Hudson JI
AD  - Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA. 
      jhudson@mclean.harvard.edu
FAU - Javaras, Kristin N
AU  - Javaras KN
FAU - Laird, Nan M
AU  - Laird NM
FAU - VanderWeele, Tyler J
AU  - VanderWeele TJ
FAU - Pope, Harrison G Jr
AU  - Pope HG Jr
FAU - Hernan, Miguel A
AU  - Hernan MA
LA  - eng
GR  - 5 T32 MN17119-22/MN/OMHHE CDC HHS/United States
GR  - R01 MH070377-01A2/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Epidemiology
JT  - Epidemiology (Cambridge, Mass.)
JID - 9009644
SB  - IM
MH  - Bipolar Disorder/epidemiology/*genetics
MH  - Bulimia/epidemiology/*genetics
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Family
MH  - Humans
MH  - *Models, Genetic
MH  - Research Design
EDAT- 2008/04/02 09:00
MHDA- 2008/08/01 09:00
CRDT- 2008/04/02 09:00
PHST- 2008/04/02 09:00 [pubmed]
PHST- 2008/08/01 09:00 [medline]
PHST- 2008/04/02 09:00 [entrez]
AID - 10.1097/EDE.0b013e31816a9de7 [doi]
PST - ppublish
SO  - Epidemiology. 2008 May;19(3):431-9. doi: 10.1097/EDE.0b013e31816a9de7.