PMID- 18380776
OWN - NLM
STAT- MEDLINE
DCOM- 20080728
LR  - 20220331
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 6
DP  - 2008 Jun
TI  - HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a 
      putative susceptibility gene in systemic lupus erythematosus.
PG  - 520-9
LID - 10.1111/j.1399-0039.2008.01037.x [doi]
AB  - Systemic lupus erythematosus (SLE) is an autoimmune disease mainly mediated by 
      the deposit of immune complexes and defects in T lymphocytes and 
      antigen-presenting cells along with a high production of T-helper 2 cytokines. A 
      tolerance-inducible function of nonclassical class Ib human leukocyte antigen 
      (HLA)-G molecule in innate and adaptive cellular responses has been reported, 
      suggesting a role in inflammatory diseases. A 14 bp sequence insertion/deletion 
      polymorphism (rs16375) in the 3'-untranslated region of the HLA-G gene has been 
      associated to the stability of HLA-G messenger RNA. The insertion of the 14 bp 
      sequence seems to be associated with lower levels of soluble HLA-G (sHLA-G). The 
      aim of this study was to evaluate the possible association of the presence of the 
      14 bp sequence (+14 bp) with SLE. We have HLA-G genotyped 200 SLE patients and 
      451 healthy control subjects (HS; Italian) and analyzed the plasma levels of 
      sHLA-G and interleukin-10 (IL-10) in a subset of SLE patients and healthy 
      subjects (Italian and Danish). A significant increase of the +14 bp HLA-G allele 
      was detected in the Italian SLE patients compared with HS [P = 0.003, OR 1.44 
      (95% CI 1.13-1.82)]. A significant increased frequency of HLA-G +14/+14 bp and a 
      decreased frequency of HLA-G -14/-14 bp were observed in SLE patients. There 
      median concentration of sHLA-G was significantly lower in the plasma of SLE 
      patients compared with that in the plasma of healthy controls (P < 0.0001). 
      Furthermore, the results confirmed higher concentrations of IL-10-positive plasma 
      in SLE patients. These results support a potential role for HLA-G in the 
      susceptibility of SLE.
FAU - Rizzo, R
AU  - Rizzo R
AD  - Department of Experimental and Diagnostic Medicine, University of Ferrara, 
      Ferrara, Italy. rbr@unife.it
FAU - Hviid, T V F
AU  - Hviid TV
FAU - Govoni, M
AU  - Govoni M
FAU - Padovan, M
AU  - Padovan M
FAU - Rubini, M
AU  - Rubini M
FAU - Melchiorri, L
AU  - Melchiorri L
FAU - Stignani, M
AU  - Stignani M
FAU - Carturan, S
AU  - Carturan S
FAU - Grappa, M T
AU  - Grappa MT
FAU - Fotinidi, M
AU  - Fotinidi M
FAU - Ferretti, S
AU  - Ferretti S
FAU - Voss, A
AU  - Voss A
FAU - Laustrup, H
AU  - Laustrup H
FAU - Junker, P
AU  - Junker P
FAU - Trotta, F
AU  - Trotta F
FAU - Baricordi, O R
AU  - Baricordi OR
LA  - eng
PT  - Journal Article
DEP - 20080329
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (IL10 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Antigen-Antibody Complex/immunology/metabolism
MH  - Antigen-Presenting Cells/immunology/metabolism
MH  - Denmark
MH  - Female
MH  - *Gene Expression Regulation/immunology
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*blood/*genetics/immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*blood/*genetics/immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunity, Innate
MH  - Interleukin-10/blood/immunology
MH  - Italy
MH  - Lupus Erythematosus, Systemic/*blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - RNA Stability/genetics/immunology
MH  - RNA, Messenger/genetics/immunology/metabolism
MH  - Th2 Cells/immunology/metabolism
EDAT- 2008/04/03 09:00
MHDA- 2008/07/29 09:00
CRDT- 2008/04/03 09:00
PHST- 2008/04/03 09:00 [pubmed]
PHST- 2008/07/29 09:00 [medline]
PHST- 2008/04/03 09:00 [entrez]
AID - TAN1037 [pii]
AID - 10.1111/j.1399-0039.2008.01037.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Jun;71(6):520-9. doi: 10.1111/j.1399-0039.2008.01037.x. 
      Epub 2008 Mar 29.