PMID- 18380778
OWN - NLM
STAT- MEDLINE
DCOM- 20080728
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 6
DP  - 2008 Jun
TI  - The study of the extended haplotypes of rare HLA-B*2730 allele using 
      microsatellite loci.
PG  - 514-9
LID - 10.1111/j.1399-0039.2008.01033.x [doi]
AB  - The aim of the present study was to compare haplotypes of the most frequent B*27 
      alleles among Croatians (B*2702 and *2705) and the rare B*2730 allele. For this 
      purpose, 37 families with members carrying human leukocyte antigen (HLA)-B27 were 
      selected. All individuals were analysed for eight microsatellites (Msats): 
      D6S2927, short tandem repeat - MHC class I-related gene (STR_MICA), D6S2793, 
      D6S2811, tumor necrosis factor a (TNFa), tumor necrosis factor d (TNFd), D6S273 
      and D6S1014, while individuals carrying the HLA-B27 specificity were subtyped. Of 
      39 analysed haplotypes, 20 individuals had B*2702, 15 subjects were positive for 
      the B*2705 allele, the B*2730 allele was found in three haplotypes from different 
      families, while one individual carried the B*2703 allele. HLA-A3 and -DRB1*16 
      were shared by all three B*2730 haplotypes. The DRB1*16 allele was also observed 
      in the majority of B*2702 haplotypes (76.5%), while HLA-A3 was, after HLA-A2, the 
      second most frequent HLA-A specificity in B*2702 haplotypes. No such correlation 
      was found for the B*2705 haplotypes. Msat analysis showed that B*2730 haplotypes 
      also share the same allele at all tested Msats. The D6S2927, D6S2793, MICA and 
      TNFd Msats were not useful in distinguishing B*2702 and B*2705 alleles because 
      D6S2927-213bp, STR_MICA-179bp, D6S2793-206bp, D6S2811-83bp and TNFd-130bp were 
      detected in almost all cases. Conversely, for the TNFa, D6S273 and D6S1014 loci, 
      haplotypes carrying B*2702 and B*2730 shared a single Msat allele in the majority 
      of cases (TNFa-113bp, D6S1014-134bp and D6S273-134bp), which was not observed for 
      B*2705 haplotypes. In conclusion, the similarity between B*2702 and B*2730 DNA 
      sequences as well as their sharing of the same haplotypic combinations 
      corroborates the proposed mechanism of B*2730 evolution from B*2702 by 
      interallelic recombination.
FAU - Grubic, Z
AU  - Grubic Z
AD  - University Hospital Centre, Zagreb, Croatia. zgrubic@kbc-zagreb.hr
FAU - Stingl, K
AU  - Stingl K
FAU - Kerhin-Brkljacic, V
AU  - Kerhin-Brkljacic V
FAU - Zunec, R
AU  - Zunec R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20080329
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A3 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*27:05 antigen)
RN  - 0 (HLA-B*27:30 antigen)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - *Alleles
MH  - Croatia
MH  - Evolution, Molecular
MH  - Family
MH  - Female
MH  - HLA-A3 Antigen/genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-B27 Antigen
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Male
MH  - Microsatellite Repeats/*genetics
MH  - Quantitative Trait Loci/*genetics
MH  - Recombination, Genetic/genetics
EDAT- 2008/04/03 09:00
MHDA- 2008/07/29 09:00
CRDT- 2008/04/03 09:00
PHST- 2008/04/03 09:00 [pubmed]
PHST- 2008/07/29 09:00 [medline]
PHST- 2008/04/03 09:00 [entrez]
AID - TAN1033 [pii]
AID - 10.1111/j.1399-0039.2008.01033.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Jun;71(6):514-9. doi: 10.1111/j.1399-0039.2008.01033.x. 
      Epub 2008 Mar 29.