PMID- 18380935
OWN - NLM
STAT- MEDLINE
DCOM- 20080617
LR  - 20170214
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 36
IP  - 2
DP  - 2008 Mar-Apr
TI  - Does the atopic phenotype prevent development of active tuberculosis infection?
PG  - 260-7
AB  - This study investigated the relationship between the atopic phenotype and the 
      development of active tuberculosis. A total of 82 human immunodeficiency virus 
      negative males with active pulmonary tuberculosis and 88 healthy controls were 
      enrolled into this prospective study. Serum immunoglobulin E (IgE) levels were 
      measured and skin prick tests performed before initiation of treatment. Skin 
      prick tests were positive in 34.1% of the tuberculosis patients and 39.8% of the 
      controls. Allergic respiratory symptoms were significantly less frequent in skin 
      prick test positive tuberculosis patients (21.4%) compared with skin prick test 
      positive controls (62.9%). Median IgE levels in atopic tuberculosis patients were 
      significantly higher than in atopic controls. The low rate of atopic respiratory 
      complaints seen in the tuberculosis patients, despite having similar allergic 
      skin prick test sensitivities to the controls, could be attributed to a weak 
      T-helper (Th) 2 immune reaction and its effects on Th1-Th2 interaction.
FAU - Kutlu, A
AU  - Kutlu A
AD  - Department of Allergy, Gulhane Military Medical Academy, Haydarpasa Teaching 
      Hospital, Istanbul, Turkey. kotiloglu@hotmail.com
FAU - Ciftci, F
AU  - Ciftci F
FAU - Bozkanat, E
AU  - Bozkanat E
FAU - Bozkurt, B
AU  - Bozkurt B
FAU - Gorur, R
AU  - Gorur R
FAU - Ozturk, S
AU  - Ozturk S
FAU - Kartaloglu, Z
AU  - Kartaloglu Z
FAU - Taskapan, O
AU  - Taskapan O
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Diagnosis, Differential
MH  - Humans
MH  - Hypersensitivity, Immediate/diagnosis/*immunology
MH  - Immunoglobulin E/biosynthesis
MH  - *Immunophenotyping
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Respiratory Hypersensitivity/diagnosis/immunology
MH  - Skin Tests
MH  - Tuberculosis, Pulmonary/diagnosis/*immunology/*prevention & control
EDAT- 2008/04/03 09:00
MHDA- 2008/06/18 09:00
CRDT- 2008/04/03 09:00
PHST- 2008/04/03 09:00 [pubmed]
PHST- 2008/06/18 09:00 [medline]
PHST- 2008/04/03 09:00 [entrez]
AID - 10.1177/147323000803600207 [doi]
PST - ppublish
SO  - J Int Med Res. 2008 Mar-Apr;36(2):260-7. doi: 10.1177/147323000803600207.