PMID- 18381784
OWN - NLM
STAT- MEDLINE
DCOM- 20080821
LR  - 20221207
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 35
IP  - 5
DP  - 2008 May
TI  - Human leukocyte antigen and clinical and demographic characteristics in psoriatic 
      arthritis and psoriasis in Chinese patients.
PG  - 891-5
AB  - OBJECTIVE: Psoriasis and psoriatic arthritis (PsA) are interrelated disorders. To 
      date, no study has compared the differences of genes between patients with PsA 
      and psoriasis and healthy controls in a Chinese population. We conducted a 
      retrospective study to determine the human leukocyte antigen (HLA) -A, -B, -Cw, 
      -DR, and -DQ alleles in Chinese patients with PsA and psoriasis. METHODS: HLA 
      studies were performed using polymerase chain reaction sequence-specific 
      oligonucleotide (PCR-SSO) genotyping methods in 91 patients with PsA and 80 with 
      psoriasis and 75 controls. Age at disease onset, sex, disease duration, 
      enthesitis, and uveitis were also analyzed. RESULTS: Among the patients with PsA 
      and psoriasis, the frequency of HLA-B27 was significantly higher in PsA and 
      HLA-A*30, -Cw*06, -DR*07 in psoriasis compared with controls. In contrast, 
      HLA-B*58 was more common in controls than in PsA and psoriasis groups, and the 
      prevalence of HLA-DR*17 was significantly higher in controls than in those with 
      psoriasis. Comparing PsA and psoriasis, the prevalence of HLA-B*27 and HLA-Cw*12 
      were more common in PsA patients, while the prevalence of HLA-DR*07 was higher in 
      those with psoriasis (p < 0.05). Among PsA patients, the association between 
      HLA-B*27 and axial joint involvement and uveitis was significant (p < 0.05). 
      CONCLUSION: Certain HLA alleles are found in Chinese patients with psoriasis 
      (HLA-A*30, -Cw*06, -DR*07) and PsA (HLA-B*27). Psoriasis patients with the 
      HLA-B*27 and/or -Cw*12 may have higher risk of developing PsA. Ours is the first 
      study to assess the genetic role of HLA in patients with psoriasis and PsA in a 
      Chinese population.
FAU - Liao, Hsien-Tzung
AU  - Liao HT
AD  - Taipei Medical University, Municipal Wan Fang Hospital, Hualien, Taiwan.
FAU - Lin, Kuan-Chia
AU  - Lin KC
FAU - Chang, Yun-Ting
AU  - Chang YT
FAU - Chen, Chun-Hsiung
AU  - Chen CH
FAU - Liang, Toong-Hua
AU  - Liang TH
FAU - Chen, Wei-Sheng
AU  - Chen WS
FAU - Su, Kuei-Ying
AU  - Su KY
FAU - Tsai, Chang-Youh
AU  - Tsai CY
FAU - Chou, Chung-Tei
AU  - Chou CT
LA  - eng
PT  - Journal Article
DEP - 20080315
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*30 antigen)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*06 antigen)
RN  - 0 (HLA-C*12 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Arthritis, Psoriatic/ethnology/*genetics/immunology
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B27 Antigen/genetics
MH  - HLA-C Antigens/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psoriasis/ethnology/*genetics/immunology
MH  - Retrospective Studies
EDAT- 2008/04/03 09:00
MHDA- 2008/08/22 09:00
CRDT- 2008/04/03 09:00
PHST- 2008/04/03 09:00 [pubmed]
PHST- 2008/08/22 09:00 [medline]
PHST- 2008/04/03 09:00 [entrez]
AID - 08/13/0329 [pii]
PST - ppublish
SO  - J Rheumatol. 2008 May;35(5):891-5. Epub 2008 Mar 15.