PMID- 18382277
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20211203
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 19
IP  - 6
DP  - 2008 Apr 16
TI  - Hypoxia-induced hypomyelination in the developing brain is mammalian target of 
      rapamycin-4E-binding protein-1 signaling dependent.
PG  - 635-9
LID - 10.1097/WNR.0b013e3282fa701c [doi]
AB  - We hypothesized that changes in the expression levels of genes in the mammalian 
      target of rapamycin are involved in the hypoxia-induced growth retardation in the 
      brain including hypomyelination. Microarray and proteomic studies showed a 
      2.3-fold increase in the expression levels of eukaryotic translation initiation 
      factor 4E-binding protein-1 and a 3-fold decrease in the levels of FK506-binding 
      protein-1 in a neonatal model of hypoxia, indicating a signal transduction 
      impairment through mammalian target of rapamycin (mTOR). Analysis of hypoxic 
      brain showed a marked decrease in the phosphorylation levels of 4E-binding 
      protein-1, suggesting a reduction of mTOR activity. These data suggest that 
      suppression of mTOR may be the mechanism underlying hypoxia-induced 
      hypomyelination observed in the developing brain.
FAU - Bilali, Faton
AU  - Bilali F
AD  - Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New 
      York 10595, USA.
FAU - Kumar, Pranav
AU  - Kumar P
FAU - Feerick, John
AU  - Feerick J
FAU - Berezin, Stuart
AU  - Berezin S
FAU - Farahani, Reza
AU  - Farahani R
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Eif4ebp1 protein, mouse)
RN  - 0 (Eukaryotic Initiation Factors)
RN  - 0 (Phosphoproteins)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 5.2.1.- (Tacrolimus Binding Proteins)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Brain/growth & development/*pathology
MH  - Carrier Proteins/*metabolism
MH  - Cell Cycle Proteins
MH  - Eukaryotic Initiation Factors
MH  - Hypoxia-Ischemia, Brain/*pathology
MH  - Mice
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Oligonucleotide Array Sequence Analysis
MH  - Phosphoproteins/*metabolism
MH  - Protein Array Analysis
MH  - Protein Kinases/*metabolism
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases
MH  - Tacrolimus Binding Proteins/metabolism
EDAT- 2008/04/03 09:00
MHDA- 2008/07/17 09:00
CRDT- 2008/04/03 09:00
PHST- 2008/04/03 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2008/04/03 09:00 [entrez]
AID - 00001756-200804160-00007 [pii]
AID - 10.1097/WNR.0b013e3282fa701c [doi]
PST - ppublish
SO  - Neuroreport. 2008 Apr 16;19(6):635-9. doi: 10.1097/WNR.0b013e3282fa701c.