PMID- 18382368
OWN - NLM
STAT- MEDLINE
DCOM- 20081021
LR  - 20080826
IS  - 1533-4066 (Electronic)
IS  - 1052-9551 (Linking)
VI  - 17
IP  - 3
DP  - 2008 Sep
TI  - Chromosome 1 analysis in chromophobe renal cell carcinomas with tissue microarray 
      (TMA)-facilitated fluorescence in situ hybridization (FISH) demonstrates loss of 
      1p/1 which is also present in renal oncocytomas.
PG  - 141-4
LID - 10.1097/PDM.0b013e3181577d57 [doi]
AB  - Morphologic overlap between chromophobe renal cell carcinoma (ChRCC) and renal 
      oncocytomas (RO) has been widely recognized. Whether these tumors are genetically 
      related and represent a spectrum of benign to malignant tumor progression remains 
      an open question. We previously showed by conventional cytogenetics and 
      fluorescent in situ hybridization (FISH) that the most common chromosomal 
      abnormality in RO is loss of chromosome 1 or 1p. In this study, we evaluated 
      chromosome 1 in ChRCC using the same set of FISH probes. Twenty-one ChRCCs from 
      13 men and 8 women were studied. Formalin-fixed, paraffin-embedded tissue blocks 
      were used to construct tissue microarrays. A subtelomeric 1p36.3 probe was used 
      in tandem with 1q25 probes for FISH studies. The patients ranged in age from 34 
      to 82 years (mean 62.8 y, median 61 y). FISH analysis showed an abnormal 
      chromosome 1 in 20/21 (95%) ChRCCs as follows: 18 tumors (85%) had loss of entire 
      chromosome 1, 2 tumors (10%) had loss of 1p36.3 only, and 1 tumor (5%) was 
      apparently diploid for chromosome 1. In this study, 95% of ChRCCs showed 
      abnormality of chromosome 1 by FISH. The progression of chromosome 1 
      abnormalities, from diploid to loss of 1p to loss of entire chromosome, is also 
      present in oncocytomas. These results provide further evidence to support a 
      genetic similarity between chromophobe carcinoma and oncocytoma. Whether 
      abnormalities of chromosome 1 are associated with RO tumorigenesis or its 
      progression to carcinoma requires further studies.
FAU - Meyer, Paul N
AU  - Meyer PN
AD  - Loyola University Medical Center, Maywood, IL 60153, USA.
FAU - Cao, Ying
AU  - Cao Y
FAU - Jacobson, Kris
AU  - Jacobson K
FAU - Krausz, Thomas
AU  - Krausz T
FAU - Flanigan, Robert C
AU  - Flanigan RC
FAU - Picken, Maria M
AU  - Picken MM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diagn Mol Pathol
JT  - Diagnostic molecular pathology : the American journal of surgical pathology, part 
      B
JID - 9204924
SB  - IM
MH  - Adenoma, Oxyphilic/*genetics/pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Renal Cell/*genetics/pathology
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Tissue Array Analysis
EDAT- 2008/04/03 09:00
MHDA- 2008/10/22 09:00
CRDT- 2008/04/03 09:00
PHST- 2008/04/03 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2008/04/03 09:00 [entrez]
AID - 10.1097/PDM.0b013e3181577d57 [doi]
PST - ppublish
SO  - Diagn Mol Pathol. 2008 Sep;17(3):141-4. doi: 10.1097/PDM.0b013e3181577d57.