PMID- 18383428
OWN - NLM
STAT- MEDLINE
DCOM- 20081027
LR  - 20220309
IS  - 1099-1557 (Electronic)
IS  - 1053-8569 (Linking)
VI  - 17
IP  - 8
DP  - 2008 Aug
TI  - The pattern of use of non-steroidal anti-inflammatory drugs (NSAIDs) from 1997 to 
      2005: a nationwide study on 4.6 million people.
PG  - 822-33
LID - 10.1002/pds.1592 [doi]
AB  - PURPOSE: To describe the nationwide pattern of use of non-steroidal 
      anti-inflammatory drugs (NSAIDs) in the Danish population. METHODS: All Danish 
      citizens aged 10 or above 1 January 1997 were included in the study. The national 
      prescription registry was used to identify all claimed prescriptions for NSAIDs 
      by the cohort until 2005. By individual-level-linkage of nationwide registries, 
      information was acquired concerning hospitalizations, comorbidity, concomitant 
      pharmacotherapy and socioeconomic factors. RESULTS: The population consisted of 
      4,614,807 individuals, of which 2,663,706 (57.8%) claimed at least one 
      prescription for NSAID from 1997 to 2005. Ibuprofen and diclofenac were the most 
      frequently used non-selective NSAIDs, whereas rofecoxib and celecoxib were the 
      most frequently used selective cyclooxygenase-2 (COX-2) inhibitors. The usage was 
      similar across all age groups. Female sex and increasing age was associated with 
      increased use of NSAID. Factors predicting extensive NSAID use were: rheumatic 
      disease (odds ratio (OR) = 1.79, 95% confidence interval (CI): 1.69-1.90), gout 
      agents (allopurinol) (OR = 2.54, CI: 2.44-2.64) and other pain medication (OR = 
      3.27, CI: 3.23-3.31). NSAIDs were most often prescribed for use for one distinct 
      treatment interval and for a short period (overall inter-quartile range [IQR]: 
      9-66 days). High doses were used in a relatively large proportion of the 
      population (8.9% for etodolac to 19.5% for celecoxib) and 54,373 (2.0%) claimed 
      prescriptions for more than one NSAID at the same time. CONCLUSION: NSAIDs were 
      commonly used in the Danish population. Since NSAIDs have been associated with 
      increased cardiovascular risk, further research on the overall risk associated 
      with these drugs on a national scale is needed.
FAU - Fosbol, Emil Loldrup
AU  - Fosbol EL
AD  - Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark. 
      elf@heart.dk
FAU - Gislason, Gunnar H
AU  - Gislason GH
FAU - Jacobsen, Soren
AU  - Jacobsen S
FAU - Abildstrom, Steen Z
AU  - Abildstrom SZ
FAU - Hansen, Morten Lock
AU  - Hansen ML
FAU - Schramm, Tina Ken
AU  - Schramm TK
FAU - Folke, Fredrik
AU  - Folke F
FAU - Sorensen, Rikke
AU  - Sorensen R
FAU - Rasmussen, Jeppe N
AU  - Rasmussen JN
FAU - Kober, Lars
AU  - Kober L
FAU - Madsen, Mette
AU  - Madsen M
FAU - Torp-Pedersen, Christian
AU  - Torp-Pedersen C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pharmacoepidemiol Drug Saf
JT  - Pharmacoepidemiology and drug safety
JID - 9208369
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Child
MH  - Denmark
MH  - Drug Utilization/*trends
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Time Factors
EDAT- 2008/04/03 09:00
MHDA- 2008/10/28 09:00
CRDT- 2008/04/03 09:00
PHST- 2008/04/03 09:00 [pubmed]
PHST- 2008/10/28 09:00 [medline]
PHST- 2008/04/03 09:00 [entrez]
AID - 10.1002/pds.1592 [doi]
PST - ppublish
SO  - Pharmacoepidemiol Drug Saf. 2008 Aug;17(8):822-33. doi: 10.1002/pds.1592.