PMID- 18383729
OWN - NLM
STAT- MEDLINE
DCOM- 20080520
LR  - 20161020
IS  - 0869-8139 (Print)
IS  - 0869-8139 (Linking)
VI  - 94
IP  - 1
DP  - 2008 Jan
TI  - [The effect of synthetic fragment 65-76 of monocyte chemiattractant protein-1 
      (MCP-1) on neointima growth after carotid artery balloon injury in rats].
PG  - 27-36
AB  - Influence of synthetic fragment 65-76 of monocyte chemoattractant protein-1 
      (MCP-1) (peptide X) on development of neointima after balloon injury of carotid 
      artery was investigated. Peptide X was introduced intramuscularly, 33 pg/kg, 
      daily during 28 days after balloon injury. In days 4 and 7 after intervention, in 
      animals receiving peptide X in comparison with control animals a substantial 
      decrease of neointimal growth was observed. On 14 and 28 days there, was no 
      significant difference in neointima development in rats with and without peptide 
      treatment. Injections of peptide X did not after the C-reactive protein 
      concentration, leukocyte number and lymphocyte subpopulations in peripheral 
      blood. Peptide X treatment along with traditional therapy may be effective in 
      preventing restenosis after angioplasty.
FAU - Kukhtina, N B
AU  - Kukhtina NB
FAU - Bashtrykov, P P
AU  - Bashtrykov PP
FAU - Bespalova, Zh D
AU  - Bespalova ZhD
FAU - Sidorova, M V
AU  - Sidorova MV
FAU - Aref'eva, T I
AU  - Aref'eva TI
FAU - Sokolov, V O
AU  - Sokolov VO
FAU - Krasnikova, T L
AU  - Krasnikova TL
LA  - rus
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Russia (Federation)
TA  - Ross Fiziol Zh Im I M Sechenova
JT  - Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
JID - 9715665
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Peptides)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Animals
MH  - C-Reactive Protein/analysis
MH  - Carotid Arteries/*metabolism/pathology
MH  - Carotid Artery Injuries/blood/*drug therapy
MH  - Chemokine CCL2/*pharmacology
MH  - Graft Occlusion, Vascular/prevention & control
MH  - Leukocyte Count
MH  - Male
MH  - Peptides/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Tunica Intima/*metabolism
EDAT- 2008/04/04 09:00
MHDA- 2008/05/21 09:00
CRDT- 2008/04/04 09:00
PHST- 2008/04/04 09:00 [pubmed]
PHST- 2008/05/21 09:00 [medline]
PHST- 2008/04/04 09:00 [entrez]
PST - ppublish
SO  - Ross Fiziol Zh Im I M Sechenova. 2008 Jan;94(1):27-36.