PMID- 18384075
OWN - NLM
STAT- MEDLINE
DCOM- 20081117
LR  - 20211020
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 147B
IP  - 7
DP  - 2008 Oct 5
TI  - Social support in older individuals: the role of the BDNF Val66Met polymorphism.
PG  - 1205-12
LID - 10.1002/ajmg.b.30754 [doi]
AB  - Although often viewed as a purely environmental construct, perception of social 
      support may be influenced by genetic factors. This study examined the 
      relationship between the brain-derived neurotrophic factor (BDNF) Val66Met 
      polymorphism and social support measures in older subjects. The sample consisted 
      of 243 depressed and 115 nondepressed older subjects, age 60 years or older; 233 
      were Val66 allele homozygotes, while 125 were Met66 allele carriers. All subjects 
      completed clinical assessments, including a self-report questionnaire assessing 
      four social support domains, and provided blood for genotyping. Statistical 
      models examined the relationship between scale scores of social support and BDNF 
      Val66Met genotype, while controlling for presence or absence of major depressive 
      disorder and other demographic factors significantly associated with social 
      support. As social support measures were not normally distributed, 
      log-transformed scores were examined. After controlling for diagnosis and 
      education level, the Met66 allele was associated with lower levels of subjective 
      social support (F(1,357) = 5.33, P = 0.0216) and a trend for fewer social 
      interactions (F(1,357) = 3.66, P = 0.0567). To our knowledge, this is the first 
      report associating a measure of social support with a genetic polymorphism. This 
      supports previous work that genetic factors may influence social support 
      perception. Further work is needed to determine the generalizability of this 
      finding to the broader population, as well as its significance for clinical 
      outcomes.
FAU - Taylor, Warren D
AU  - Taylor WD
AD  - Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 
      27710, USA. taylo066@mc.duke.edu
FAU - Zuchner, Stephan
AU  - Zuchner S
FAU - McQuoid, Douglas R
AU  - McQuoid DR
FAU - Steffens, David C
AU  - Steffens DC
FAU - Blazer, Dan G
AU  - Blazer DG
FAU - Krishnan, K Ranga R
AU  - Krishnan KR
LA  - eng
GR  - P50 MH060451/MH/NIMH NIH HHS/United States
GR  - P50 MH60451/MH/NIMH NIH HHS/United States
GR  - R01 MH054846/MH/NIMH NIH HHS/United States
GR  - P50 MH060451-01A2/MH/NIMH NIH HHS/United States
GR  - K23 MH065939/MH/NIMH NIH HHS/United States
GR  - P30 ES011961/ES/NIEHS NIH HHS/United States
GR  - K23 MH065939-05/MH/NIMH NIH HHS/United States
GR  - R01 MH054846-05/MH/NIMH NIH HHS/United States
GR  - R01 MH54846/MH/NIMH NIH HHS/United States
GR  - K23 MH65939/MH/NIMH NIH HHS/United States
GR  - ES11961/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Depression
MH  - Genotype
MH  - Humans
MH  - Interpersonal Relations
MH  - Middle Aged
MH  - *Mutation, Missense
MH  - *Perception
MH  - Personality Tests
MH  - Polymorphism, Single Nucleotide
MH  - *Social Support
MH  - Surveys and Questionnaires
PMC - PMC2575229
MID - NIHMS74625
EDAT- 2008/04/04 09:00
MHDA- 2008/11/18 09:00
PMCR- 2009/10/05
CRDT- 2008/04/04 09:00
PHST- 2008/04/04 09:00 [pubmed]
PHST- 2008/11/18 09:00 [medline]
PHST- 2008/04/04 09:00 [entrez]
PHST- 2009/10/05 00:00 [pmc-release]
AID - 10.1002/ajmg.b.30754 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1205-12. doi: 
      10.1002/ajmg.b.30754.