PMID- 18384488
OWN - NLM
STAT- MEDLINE
DCOM- 20080728
LR  - 20131121
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 6
DP  - 2008 Jun
TI  - Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients 
      with coronary artery disease.
PG  - 530-7
LID - 10.1111/j.1399-0039.2008.01038.x [doi]
AB  - Periodontitis and coronary artery disease (CAD) are inflammatory diseases and 
      associated with each other. The major histocompatibility complex (MHC) region 
      carries genes involved in immune response and inflammation. We investigated 
      whether the MHC genes correlate with the presence of periodontitis or with the 
      occurrence of periodontal pathogens in patients with CAD. Blood and saliva 
      samples from CAD patients (n = 106) were collected at the time of 
      hospitalization. Nine MHC genetic markers [human leukocyte antigen (HLA)-A, 
      HLA-B, HLA-DRB1, lymphotoxin alpha (LTA) +253(a/g), +496(C/T), +633(c/g), 
      +724(C/A), C4A and C4B)] were typed. Based on panoramic tomography, patients were 
      categorized into nonperiodontitis and periodontitis groups. Two major periodontal 
      pathogens, Aggregatibacter (Actinobacillus) actinomycetemcomitans and 
      Porphyromonas gingivalis, were cultivated and polymerase chain reaction-amplified 
      from salivary samples. Serum immunoglobulin (Ig)A and IgG antibody levels to 
      these pathogens were measured. In the univariate analysis, LTA+496C allele (OR = 
      5.29; 95% CI = 2.07-13.51, P = 0.00027), and the occurrence of P. gingivalis in 
      saliva (OR = 4.74; 95% CI = 1.64-13.70; P = 0.002) were more frequent in 
      periodontitis when compared with nonperiodontitis. Similarly, serum IgA antibody 
      level against the pathogen was increased in periodontitis (P = 0.048). In the 
      multiple logistic regression analysis, when a wide range of covariates was 
      included, the LTA+496C allele (OR = 10.87; 95% CI = 3.23-36.60; P = 0.00012) and 
      the elevated serum IgA antibody level against P. gingivalis (OR = 1.56; 95% CI = 
      1.05-2.30; P = 0.026) remained as significant risk factors for periodontitis. In 
      conclusion, the major finding of this study is that the LTA+496C allele is 
      associated with periodontitis in patients with CAD.
FAU - Palikhe, A
AU  - Palikhe A
AD  - Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
FAU - Lokki, M-L
AU  - Lokki ML
FAU - Pussinen, P J
AU  - Pussinen PJ
FAU - Paju, S
AU  - Paju S
FAU - Ahlberg, J
AU  - Ahlberg J
FAU - Asikainen, S
AU  - Asikainen S
FAU - Seppanen, M
AU  - Seppanen M
FAU - Valtonen, V
AU  - Valtonen V
FAU - Nieminen, M S
AU  - Nieminen MS
FAU - Sinisalo, J
AU  - Sinisalo J
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20080402
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Lymphotoxin-alpha)
SB  - IM
MH  - Aggregatibacter actinomycetemcomitans
MH  - *Alleles
MH  - Antibodies, Bacterial/blood
MH  - Coronary Artery Disease/blood/complications/*genetics/microbiology
MH  - Female
MH  - Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/genetics/metabolism
MH  - Humans
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin G/blood
MH  - Inflammation/blood/etiology/genetics/microbiology
MH  - Lymphotoxin-alpha/blood/*genetics
MH  - Male
MH  - Middle Aged
MH  - Periodontitis/blood/etiology/*genetics/microbiology
MH  - Porphyromonas gingivalis
MH  - Risk Factors
MH  - Saliva/metabolism
EDAT- 2008/04/04 09:00
MHDA- 2008/07/29 09:00
CRDT- 2008/04/04 09:00
PHST- 2008/04/04 09:00 [pubmed]
PHST- 2008/07/29 09:00 [medline]
PHST- 2008/04/04 09:00 [entrez]
AID - TAN1038 [pii]
AID - 10.1111/j.1399-0039.2008.01038.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Jun;71(6):530-7. doi: 10.1111/j.1399-0039.2008.01038.x. 
      Epub 2008 Apr 2.