PMID- 18388176
OWN - NLM
STAT- MEDLINE
DCOM- 20081104
LR  - 20221207
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 79
IP  - 11
DP  - 2008 Nov
TI  - Narcolepsy in Southern Chinese patients: clinical characteristics, HLA typing and 
      seasonality of birth.
PG  - 1262-7
LID - 10.1136/jnnp.2007.143420 [doi]
AB  - OBJECTIVE: To report clinical characteristics, human leukocyte antigen (HLA) 
      typing and seasonality of birth of a series of 54 Southern Chinese patients 
      suffering from narcolepsy. METHODS: All subjects underwent detailed medical and 
      psychiatric interviews and a standardised nocturnal polysomnogram followed by a 
      daytime Multiple Sleep Latency Test. Each subject also completed a set of sleep 
      questionnaires. HLA typing was performed in 91% of subjects. RESULTS: A total of 
      78% and 22% of patients were diagnosed with suffering from cataplectic and 
      non-cataplectic narcolepsy, respectively. The majority (n = 47, 87%) of patients 
      were referred to our sleep clinic for excessive daytime sleepiness (EDS). The 
      cataplectic narcolepsy differed from non-cataplectic narcolepsy by having more 
      rapid eye movement (REM)-related clinical symptoms (more sleep paralysis and 
      sleep-related hallucination) and sleep disturbances (shorter REM latency), as 
      well as tighter association with HLA DQB1*0602. A bi-modal peak pattern was 
      observed at 11 and 39 years old. A similar bi-modal pattern also occurred for EDS 
      and cataplexy. Excess winter births were observed for this series of patients. 
      81% of patients with cataplectic narcolepsy were DQB1*0602-positive. There were 
      no differences between early- and late-onset cases in the association with 
      positive DQB1*0602 (71.4% vs 60%). Narcolepsy had prominent pernicious effects on 
      various social, academic, family and mental aspects in our patients. CONCLUSIONS: 
      In our Southern Chinese narcolepsy series, bi-modal peak pattern of age of onset, 
      excess winter birth and tight association of HLA DQB1*0602 with cataplectic 
      narcolepsy were found.
FAU - Wing, Y K
AU  - Wing YK
AD  - Department of Psychiatry, Shatin Hospital, The Chinese University of Hong Kong, 
      Prince of Wales and Shatin Hospitals, Shatin, Hong Kong SAR. ykwing@cuhk.edu.hk
FAU - Chen, L
AU  - Chen L
FAU - Fong, S Y Y
AU  - Fong SY
FAU - Ng, M H L
AU  - Ng MH
FAU - Ho, C K W
AU  - Ho CK
FAU - Cheng, S H
AU  - Cheng SH
FAU - Tang, N L S
AU  - Tang NL
FAU - Li, A M
AU  - Li AM
LA  - eng
PT  - Journal Article
DEP - 20080403
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People/*statistics & numerical data
MH  - Catchment Area, Health
MH  - Child
MH  - China/epidemiology
MH  - Female
MH  - Genotype
MH  - HLA Antigens/*immunology
MH  - HLA-DQ Antigens/immunology
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/immunology
MH  - Middle Aged
MH  - Narcolepsy/*epidemiology/genetics/*immunology
MH  - Parturition
MH  - Prevalence
MH  - *Seasons
EDAT- 2008/04/05 09:00
MHDA- 2008/11/05 09:00
CRDT- 2008/04/05 09:00
PHST- 2008/04/05 09:00 [pubmed]
PHST- 2008/11/05 09:00 [medline]
PHST- 2008/04/05 09:00 [entrez]
AID - jnnp.2007.143420 [pii]
AID - 10.1136/jnnp.2007.143420 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2008 Nov;79(11):1262-7. doi: 
      10.1136/jnnp.2007.143420. Epub 2008 Apr 3.