PMID- 18388897
OWN - NLM
STAT- MEDLINE
DCOM- 20080908
LR  - 20171116
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 16
IP  - 6
DP  - 2008 Jun
TI  - Short-term training effects on diastolic function in obese persons with the 
      metabolic syndrome.
PG  - 1277-83
LID - 10.1038/oby.2008.212 [doi]
AB  - The aim of this study was to determine the effects of a short-term high-intensity 
      exercise program on diastolic function and glucose tolerance in obese individuals 
      with and without metabolic syndrome (MetSyn). Obese men and women (BMI > 30 
      kg/m(2); 39-60 years) with and without the MetSyn (MetSyn 13; non-MetSyn 18) 
      underwent exercise training consisting of 10 consecutive days of treadmill 
      walking for 1 h/day at 70-75% of peak aerobic capacity. Subjects performed pre- 
      and post-training testing for aerobic capacity, glucose tolerance (2-h meal 
      test), and standard echocardiography. Aerobic capacity improved for both groups 
      (non-MetSyn 24.0 +/- 1.6 ml/kg/min vs. 25.1 +/- 1.5 ml/kg/min; MetSyn 25.2 +/- 
      1.8 ml/kg/min vs. 26.2 +/- 1.7 ml/kg/min, P < 0.05). Glucose area under the curve 
      (AUC) improved in the MetSyn group (1,017 +/- 58 pmol/l/min vs. 883 +/- 75 
      pmol/l/min, P < 0.05) with no change for the non-MetSyn group (685 +/- 54 
      pmol/l/min vs. 695 +/- 70 pmol/l/min). Isovolumic relaxation time (IVRT) improved 
      in the MetSyn group (97 +/- 6 ms vs. 80 +/- 5 ms, P < 0.05), and remained normal 
      in the non-MetSyn group (82 +/- 6 ms vs. 86 +/- 5 ms). No changes in other 
      diastolic parameters were observed. The overall reduction in IVRT was correlated 
      with a decrease in diastolic blood pressure (DBP) (r = 0.45, P < 0.05), but not 
      with changes in glucose tolerance. Body weight did not change with training in 
      either group. A 10-day high-intensity exercise program improved diastolic 
      function and glucose tolerance in the group with MetSyn. The reduction in IVRT in 
      MetSyn was associated with a fall in blood pressure. These data suggest that it 
      may be possible to reverse early parameters of diastolic dysfunction in MetSyn 
      with a high-intensity exercise program.
FAU - Baynard, Tracy
AU  - Baynard T
AD  - Department of Exercise Science, Syracuse University, Syracuse, New York, USA. 
      tbaynard@uiuc.edu
FAU - Carhart, Robert L Jr
AU  - Carhart RL Jr
FAU - Ploutz-Snyder, Lori L
AU  - Ploutz-Snyder LL
FAU - Weinstock, Ruth S
AU  - Weinstock RS
FAU - Kanaley, Jill A
AU  - Kanaley JA
LA  - eng
GR  - R21 DK063179/DK/NIDDK NIH HHS/United States
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080403
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Blood Pressure/*physiology
MH  - Body Weight/physiology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Insulin/metabolism
MH  - Male
MH  - Metabolic Syndrome/*physiopathology/*therapy
MH  - Middle Aged
MH  - Obesity/*physiopathology/*therapy
EDAT- 2008/04/05 09:00
MHDA- 2008/09/09 09:00
CRDT- 2008/04/05 09:00
PHST- 2008/04/05 09:00 [pubmed]
PHST- 2008/09/09 09:00 [medline]
PHST- 2008/04/05 09:00 [entrez]
AID - oby2008212 [pii]
AID - 10.1038/oby.2008.212 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2008 Jun;16(6):1277-83. doi: 10.1038/oby.2008.212. Epub 
      2008 Apr 3.