PMID- 18389298
OWN - NLM
STAT- MEDLINE
DCOM- 20080930
LR  - 20211020
IS  - 1367-5435 (Print)
IS  - 1367-5435 (Linking)
VI  - 35
IP  - 7
DP  - 2008 Jul
TI  - Seawater requirement for the production of lipoxazolidinones by marine 
      actinomycete strain NPS8920.
PG  - 761-5
LID - 10.1007/s10295-008-0344-7 [doi]
AB  - A novel marine actinomycete strain NPS8920 produces a new class of 
      4-oxazolidinone antibiotics lipoxazolidinone A, B and C. Lipoxazolidinone A 
      possesses good potency (1-2 microg/mL) against drug-resistant pathogens 
      methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant 
      Enterococcus faecium (VRE). Strain NPS8920 exhibits different morphologies in 
      both agar and submerged cultures. The ability of strain NPS8920 to sporulate on 
      saline-based agar media but not on deionized water-based agar medium supported 
      that strain NPS8920 is a marine actinomycete. While strain NPS8920 does not 
      require seawater for growth, the production of lipoxazolidinones by strain 
      NPS8920 can only be detected in the seawater-based media. The optimal production 
      of lipoxazolidinones was observed in the natural seawater-based medium. Strain 
      NPS8920 produced 10-20% of lipoxazolidinones in the synthetic sea salt Instant 
      Ocean-based medium and no production in the sodium chloride-based and deionized 
      water-based media.
FAU - Sunga, Michelle J
AU  - Sunga MJ
AD  - Nereus Pharmaceuticals, Inc, 10480 Wateridge Circle, San Diego, CA 92121, United 
      States.
FAU - Teisan, Sy
AU  - Teisan S
FAU - Tsueng, Ginger
AU  - Tsueng G
FAU - Macherla, Venkat R
AU  - Macherla VR
FAU - Lam, Kin S
AU  - Lam KS
LA  - eng
PT  - Journal Article
DEP - 20080404
PL  - Germany
TA  - J Ind Microbiol Biotechnol
JT  - Journal of industrial microbiology & biotechnology
JID - 9705544
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Culture Media)
RN  - 0 (Oxazolidinones)
RN  - 0 (lipoxazolidinone A)
RN  - 0 (lipoxazolidinone B)
RN  - 0 (lipoxazolidinone C)
SB  - IM
MH  - Actinobacteria/*growth & development/*metabolism
MH  - Anti-Bacterial Agents/*metabolism
MH  - Culture Media/chemistry
MH  - Molecular Structure
MH  - Oxazolidinones/*metabolism
MH  - Seawater/*microbiology
EDAT- 2008/04/05 09:00
MHDA- 2008/10/01 09:00
CRDT- 2008/04/05 09:00
PHST- 2008/02/01 00:00 [received]
PHST- 2008/03/20 00:00 [accepted]
PHST- 2008/03/17 00:00 [revised]
PHST- 2008/04/05 09:00 [pubmed]
PHST- 2008/10/01 09:00 [medline]
PHST- 2008/04/05 09:00 [entrez]
AID - 10.1007/s10295-008-0344-7 [doi]
PST - ppublish
SO  - J Ind Microbiol Biotechnol. 2008 Jul;35(7):761-5. doi: 10.1007/s10295-008-0344-7. 
      Epub 2008 Apr 4.