PMID- 18389442
OWN - NLM
STAT- MEDLINE
DCOM- 20090114
LR  - 20171116
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 37
IP  - 3
DP  - 2008
TI  - Estrogen modulates bone marrow-derived DCs in SLE murine model-(NZB x NZW) F1 
      female mice.
PG  - 227-43
LID - 10.1080/08820130801973328 [doi]
AB  - Dendritic cells (DCs) in the patient and animal models of systemic lupus 
      erythematosus (SLE) are abnormal, but the detailed mechanism is unclear. Estrogen 
      can modulate DCs in biological condition and estrogen concentration is related to 
      the onset and development of SLE. So the control of estrogen on DCs might lead to 
      the disorder of DCs. To prove the hypothesis, we detected the effects of 
      17beta-estradiol (E2) on bone marrow (BM)-derived DCs in SLE murine model-(NZB x 
      NZW) F1 (NZB/w F1) female mice before and after the disease onset. We found that 
      E2 mainly enhanced the expression of surface molecule CD40, MHCII and the 
      stimulation activity of immature DCs, but weakened the activity of mature DCs. E2 
      decreased the production of cytokines IL-6, IL-10, IL-12 and TNFalpha of DCs in 
      young mice, but increased them in old mice. Tamoxifen could antagonize the E2 
      effect. E2 changed the expression of estrogen receptor-alpha (ER alpha) in DCs. 
      The level of ER alpha in DCs of various old mice and the differentiation states 
      varied. The results suggest that E2 can modulate the functions of BM-derived DCs 
      in SLE pathology. The modulation is achieved by binding ER. The effects of E2 on 
      DCs are different depending on the progression of SLE and cell differentiation 
      status. This might be due to the difference of ER expression.
FAU - Jiang, Bo
AU  - Jiang B
AD  - Immunology and Reproductive Biology Lab, Medical School & State Key Laboratory of 
      Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China.
FAU - Sun, Lingyun
AU  - Sun L
FAU - Hao, Sha
AU  - Hao S
FAU - Li, Xiaoxi
AU  - Li X
FAU - Xu, Yixin
AU  - Xu Y
FAU - Hou, Yayi
AU  - Hou Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (CD40 Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogens)
RN  - 0 (Selective Estrogen Receptor Modulators)
RN  - 094ZI81Y45 (Tamoxifen)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Antigen Presentation
MH  - Bone Marrow Cells/*drug effects/immunology
MH  - CD40 Antigens/immunology/metabolism
MH  - Cell Differentiation
MH  - Cytokines/biosynthesis/immunology
MH  - Dendritic Cells/drug effects/*immunology
MH  - Estradiol/*immunology/pharmacology
MH  - Estrogen Receptor alpha/biosynthesis/immunology
MH  - Estrogens/*immunology/pharmacology
MH  - Female
MH  - Gene Expression Regulation
MH  - Humans
MH  - Lupus Erythematosus, Systemic/immunology
MH  - Mice
MH  - Mice, Inbred NZB
MH  - Selective Estrogen Receptor Modulators/immunology/pharmacology
MH  - Tamoxifen/immunology/pharmacology
EDAT- 2008/04/05 09:00
MHDA- 2009/01/15 09:00
CRDT- 2008/04/05 09:00
PHST- 2008/04/05 09:00 [pubmed]
PHST- 2009/01/15 09:00 [medline]
PHST- 2008/04/05 09:00 [entrez]
AID - 791931933 [pii]
AID - 10.1080/08820130801973328 [doi]
PST - ppublish
SO  - Immunol Invest. 2008;37(3):227-43. doi: 10.1080/08820130801973328.