PMID- 18391468
OWN - NLM
STAT- MEDLINE
DCOM- 20080801
LR  - 20131121
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 72
IP  - 4
DP  - 2008 Apr
TI  - Oral administration of a hop water extract ameliorates the development of 
      dermatitis induced by the periodical topical application of a mite antigen in 
      atopic dermatitis model NC/Nga mice.
PG  - 974-81
AB  - We investigated the inhibitory effect of an oral administration of a hop water 
      extract (HWE) on the development of dermatitis by using NC/Nga atopic dermatitis 
      model mice. The induction of allergic dermatitis was conducted by tape-stripping 
      and topical application of a mite antigen (Dermatophagoides farinae) on to the 
      ear once a week for 10 weeks. HWE was orally administered at a dose of 100 or 500 
      mg/kg. The total immunoglobulin E (IgE) concentration in serum and the ear 
      thickness were periodically examined. Finally, the antigen-specific IgE level in 
      the serum and the production of interleukin (IL)-4, IL-12 and interferon 
      (IFN)-gamma from splenocytes and cervical lymph node cells were measured. The 
      oral administration of HWE significantly inhibited the increase of total IgE 
      production and ear swelling throughout the experimental period. The production of 
      IL-12 was significantly lower in the HWE administered group than in the control 
      group. The results suggest that the intake of HWE may be effective in preventing 
      and alleviating the development of atopic dermatitis-like skin disease.
FAU - Segawa, Shuichi
AU  - Segawa S
AD  - Frontier Laboratories of Value Creation, Sapporo Breweries Ltd, 10 Okatohme, 
      Yaizu, Shizuoka 425-0013, Japan. syuuichi.segawa@sapporobeer.co.jp
FAU - Kuroda, Hisao
AU  - Kuroda H
FAU - Kaneko, Takafumi
AU  - Kaneko T
FAU - Watari, Junji
AU  - Watari J
LA  - eng
PT  - Journal Article
DEP - 20080407
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 059QF0KO0R (Water)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antibody Specificity
MH  - Antigens, Dermatophagoides/*immunology/metabolism
MH  - Cervix Uteri/cytology
MH  - Cytokines/metabolism
MH  - Dermatitis, Atopic/*immunology/metabolism/pathology/*prevention & control
MH  - Disease Models, Animal
MH  - Ear/pathology
MH  - Female
MH  - Humulus/*chemistry
MH  - Immunoglobulin E/blood/immunology
MH  - Lymph Nodes/drug effects
MH  - Macrophages/drug effects
MH  - Mice
MH  - Plant Extracts/*administration & dosage/*pharmacology
MH  - Spleen/cytology
MH  - Time Factors
MH  - Water/*chemistry
EDAT- 2008/04/09 09:00
MHDA- 2008/08/02 09:00
CRDT- 2008/04/09 09:00
PHST- 2008/04/09 09:00 [pubmed]
PHST- 2008/08/02 09:00 [medline]
PHST- 2008/04/09 09:00 [entrez]
AID - JST.JSTAGE/bbb/70695 [pii]
AID - 10.1271/bbb.70695 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2008 Apr;72(4):974-81. doi: 10.1271/bbb.70695. Epub 
      2008 Apr 7.