PMID- 18391638
OWN - NLM
STAT- MEDLINE
DCOM- 20080717
LR  - 20080408
IS  - 1741-8267 (Print)
IS  - 1741-8267 (Linking)
VI  - 15
IP  - 2
DP  - 2008 Apr
TI  - Exercise training increases oxygen uptake efficiency slope in chronic heart 
      failure.
PG  - 140-4
LID - 10.1097/HJR.0b013e3282ef19986 [doi]
AB  - BACKGROUND AND AIM: The oxygen uptake efficiency slope (OUES) is a novel measure 
      of cardiopulmonary reserve. OUES is measured during an exercise test, but it is 
      independent of the maximally achieved exercise intensity. It has a higher 
      prognostic value in chronic heart failure (CHF) than other exercise test-derived 
      variables such as(Equation is included in full-text article.)or(Equation is 
      included in full-text article.)slope. Exercise training improves(Equation is 
      included in full-text article.)and(Equation is included in full-text article.)in 
      CHF patients. We hypothesized that exercise training also improves OUES. METHODS 
      AND RESULTS: We studied 34 New York Heart Association (NYHA) class II-III CHF 
      patients who constituted an exercise training group T (N=20; 19 men/1 woman; age 
      60+/-9 years; left ventricular ejection fraction 34+/-5%) and a control group C 
      (N=14; 13 men/one woman; age 63+/-10 years; left ventricular ejection fraction 
      34+/-7%). A symptom-limited exercise test was performed at baseline and repeated 
      after 4 weeks (C) or after completion of the training program (T). Exercise 
      training increased NYHA class from 2.6 to 2.0 (P<0.05),(Equation is included in 
      full-text article.)by 14% [P(TvsC)<0.01], and OUES by 19% [P(TvsC)<0.01]. 
      Exercise training decreased(Equation is included in full-text article.)by 14% 
      [P(TvsC)<0.05]. CONCLUSION: Exercise training improved NYHA class,(Equation is 
      included in full-text article.)and also OUES. This finding is of great potential 
      interest as OUES is insensitive for peak load. Follow-up studies are needed to 
      demonstrate whether OUES improvements induced by exercise training are associated 
      with improved prognosis.
FAU - Gademan, Maaike G J
AU  - Gademan MG
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Swenne, Cees A
AU  - Swenne CA
FAU - Verwey, Harriette F
AU  - Verwey HF
FAU - van de Vooren, Hedde
AU  - van de Vooren H
FAU - Haest, Joris C W
AU  - Haest JC
FAU - van Exel, Henk J
AU  - van Exel HJ
FAU - Lucas, Caroline M H B
AU  - Lucas CM
FAU - Cleuren, Ger V J
AU  - Cleuren GV
FAU - Schalij, Martin J
AU  - Schalij MJ
FAU - van der Wall, Ernst E
AU  - van der Wall EE
LA  - eng
GR  - HL078797-01A1/HL/NHLBI NIH HHS/United States
GR  - British Heart Foundation/United Kingdom
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Cardiovasc Prev Rehabil
JT  - European journal of cardiovascular prevention and rehabilitation : official 
      journal of the European Society of Cardiology, Working Groups on Epidemiology & 
      Prevention and Cardiac Rehabilitation and Exercise Physiology
JID - 101192000
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Exercise Test
MH  - *Exercise Therapy
MH  - Female
MH  - Heart Failure/metabolism/physiopathology/*rehabilitation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxygen Consumption
MH  - Pulmonary Ventilation
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Function, Left
EDAT- 2008/04/09 09:00
MHDA- 2008/07/18 09:00
CRDT- 2008/04/09 09:00
PHST- 2008/04/09 09:00 [pubmed]
PHST- 2008/07/18 09:00 [medline]
PHST- 2008/04/09 09:00 [entrez]
AID - 00149831-200804000-00004 [pii]
AID - 10.1097/HJR.0b013e3282ef19986 [doi]
PST - ppublish
SO  - Eur J Cardiovasc Prev Rehabil. 2008 Apr;15(2):140-4. doi: 
      10.1097/HJR.0b013e3282ef19986.