PMID- 18392037
OWN - NLM
STAT- MEDLINE
DCOM- 20080915
LR  - 20220317
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 32
IP  - 7
DP  - 2008 Jul
TI  - Human serum levels of fetal antigen 1 (FA1/Dlk1) increase with obesity, are 
      negatively associated with insulin sensitivity and modulate inflammation in 
      vitro.
PG  - 1122-9
LID - 10.1038/ijo.2008.40 [doi]
AB  - OBJECTIVE: To investigate fetal antigen 1 (FA1) protein within the context of 
      human obesity and its relation with insulin sensitivity. SUBJECTS: 
      Cross-sectional study that analyses circulating levels of FA1 in two selected 
      human cohorts: n=127 men for the study of FA1 circulating levels in the context 
      of obesity and insulin sensitivity (S(i)); and n=61 severely obese women before 
      and after bariatric surgery. The response in vitro to FA1 protein on human cell 
      lines of monocytes, preadipocytes and mature adipocytes was studied. 
      MEASUREMENTS: Anthropometrical parameters: body mass index, waist-to-hip ratio, 
      waist circumference, fat-free mass and fat mass. Clinical parameters: lipid 
      profile (high-density lipoprotein (HDL) cholesterol, low-density lipoprotein 
      (LDL) cholesterol, total cholesterol, triglycerides), glycemic profile (fasting 
      glucose, insulin, S(i), HOMA-IR (Homeostasis Model Assessment of Insulin 
      Resistance), cytokines (sIL-6), adipokines (adiponectin) and circulating soluble 
      fractions of tumor necrosis factor-alpha receptors 1 and 2 (sTNFR1 and sTNFR2). 
      RESULTS: IN the obesity study, levels of FA1 in serum were found to increase with 
      obesity. The S(i) index was negatively dependent on FA1 levels. In severe 
      obesity, serum levels of FA1 decreased 1.4-fold 6 months after bariatric surgery. 
      In vitro assays with FA1 protein on human monocytes and adipocytes cell lines 
      modified the expression of pro-inflammatory cytokines and adipokines (tumor 
      necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), 
      IL-6 (interleukin-6) and adiponectin). CONCLUSION: FA1 serum levels were 
      increased in obese subjects and might influence S(i). The stimulatory effect of 
      FA1 protein on pro-inflammatory cytokines on both immune and adipose cell types 
      could contribute to worsening the inflammatory environment observed in obesity.
FAU - Chacon, M R
AU  - Chacon MR
AD  - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas, 
      University Hospital of Tarragona Joan XXIII, Pere Virgili Institute, Universitat 
      Rovira i Virgili, Tarragona, Spain.
FAU - Miranda, M
AU  - Miranda M
FAU - Jensen, C H
AU  - Jensen CH
FAU - Fernandez-Real, J M
AU  - Fernandez-Real JM
FAU - Vilarrasa, N
AU  - Vilarrasa N
FAU - Gutierrez, C
AU  - Gutierrez C
FAU - Naf, S
AU  - Naf S
FAU - Gomez, J M
AU  - Gomez JM
FAU - Vendrell, J
AU  - Vendrell J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080408
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Adipokines)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Cytokines)
RN  - 0 (DLK1 protein, human)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
SB  - IM
MH  - Adipocytes/drug effects/metabolism
MH  - Adipokines/analysis/metabolism
MH  - Adult
MH  - Bariatric Surgery
MH  - Calcium-Binding Proteins
MH  - Cell Line
MH  - Cross-Sectional Studies
MH  - Cytokines/analysis/metabolism
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Intercellular Signaling Peptides and Proteins/*blood/pharmacology
MH  - Linear Models
MH  - Male
MH  - Membrane Proteins/*blood/pharmacology
MH  - Middle Aged
MH  - Monocytes/drug effects/metabolism
MH  - Obesity/*blood/immunology
MH  - Obesity, Morbid/blood/immunology
MH  - Overweight/blood/immunology
MH  - Postoperative Period
EDAT- 2008/04/09 09:00
MHDA- 2008/09/16 09:00
CRDT- 2008/04/09 09:00
PHST- 2008/04/09 09:00 [pubmed]
PHST- 2008/09/16 09:00 [medline]
PHST- 2008/04/09 09:00 [entrez]
AID - ijo200840 [pii]
AID - 10.1038/ijo.2008.40 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2008 Jul;32(7):1122-9. doi: 10.1038/ijo.2008.40. Epub 2008 Apr 
      8.