PMID- 18393250
OWN - NLM
STAT- MEDLINE
DCOM- 20090319
LR  - 20080408
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 25
IP  - 2
DP  - 2008 Apr
TI  - [The cytogenetic features of Burkitt leukemia].
PG  - 214-7
AB  - OBJECTIVE: To evaluate the incidence of chromosomal abnormalities in Burkitt 
      leukemia (BL). METHODS: Conventional cytogenetics (CC) was carried out to detect 
      the karyotypes. Meanwhile, three color interphase fluorescence in situ 
      hybridization (FISH) was used to detect the t(8;14)(q24;q32) in 17 newly 
      diagnosed BL. RESULTS: The results showed that the incidence of chromosomal 
      abnormalities was 41.2% (7/17) by CC technique, including one of each for simple 
      t(8;14)(q24;q32), complex chromosomal abnormality containing t(8;14)(q24;q32), 
      t(8;22)(q24;q11), the complex chromosomal abnormality of t(12;22)(?;?), 
      t(2;13)(?;?) with + 12, and one with two marker chromosomes. FISH method detected 
      eight cases of t(8;14)(q24;q32), including the two detected by CC technique. Five 
      samples (5/8) showed 2A1G1O2F (two blue, one green, one orange and two yellow 
      signals in interphase nuclei), while three samples (3/8) showed 2A1G1O1F(two 
      blue, one green, one orange and one yellow signals in interphase nuclei). 
      CONCLUSION: Two different breakpoints have been identified on the c-Myc locus on 
      8q24. Interphase FISH was more sensitive in detecting t(8;14)(q24;q32), and it is 
      an important complement to CC. It should be used as a routine method for 
      diagnosis of BL.
FAU - Xie, Xiaoyan
AU  - Xie X
AD  - Department of Hematology, the First Affiliated Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu, 210029 P. R. China. xxy8848@hotmail.com
FAU - Xu, Wei
AU  - Xu W
FAU - Qiu, Hairong
AU  - Qiu H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Burkitt Lymphoma/*genetics
MH  - *Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2008/04/09 09:00
MHDA- 2009/03/20 09:00
CRDT- 2008/04/09 09:00
PHST- 2008/04/09 09:00 [pubmed]
PHST- 2009/03/20 09:00 [medline]
PHST- 2008/04/09 09:00 [entrez]
AID - 940625047 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Apr;25(2):214-7.