PMID- 18394479
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20220330
IS  - 0079-6123 (Print)
IS  - 1875-7855 (Electronic)
IS  - 0079-6123 (Linking)
VI  - 169
DP  - 2008
TI  - Persistent neural activity in the prefrontal cortex: a mechanism by which BDNF 
      regulates working memory?
PG  - 251-66
LID - 10.1016/S0079-6123(07)00015-5 [doi]
AB  - Working memory is the ability to maintain representations of task-relevant 
      information for short periods of time to guide subsequent actions or make 
      decisions. Neurons of the prefrontal cortex exhibit persistent firing during the 
      delay period of working memory tasks. Despite extensive studies, the mechanisms 
      underlying this persistent neural activity remain largely obscure. The 
      neurotransmitter systems of dopamine, NMDA, and GABA have been implicated, but 
      further investigations are necessary to establish their precise roles and 
      relationships. Recent research has suggested a new component: brain-derived 
      neurotrophic factor (BDNF) and its high-affinity receptor, TrkB. We review the 
      research on persistent activity and suggest that BDNF/TrkB signaling in a 
      distinct class of interneurons plays an important role in organizing persistent 
      neural activity at the single-neuron and network levels.
FAU - Galloway, Evan M
AU  - Galloway EM
AD  - Section on Neural Development and Plasticity, NICHD, National Institutes of 
      Health, Bethesda, MD, USA.
FAU - Woo, Newton H
AU  - Woo NH
FAU - Lu, Bai
AU  - Lu B
LA  - eng
GR  - Z01 HD000714-12/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Netherlands
TA  - Prog Brain Res
JT  - Progress in brain research
JID - 0376441
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Memory, Short-Term/*physiology
MH  - Neurons/*physiology
MH  - Prefrontal Cortex/*cytology/physiology
PMC - PMC4163787
MID - NIHMS620225
EDAT- 2008/04/09 09:00
MHDA- 2008/08/30 09:00
PMCR- 2014/09/15
CRDT- 2008/04/09 09:00
PHST- 2008/04/09 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/04/09 09:00 [entrez]
PHST- 2014/09/15 00:00 [pmc-release]
AID - S0079-6123(07)00015-5 [pii]
AID - 10.1016/S0079-6123(07)00015-5 [doi]
PST - ppublish
SO  - Prog Brain Res. 2008;169:251-66. doi: 10.1016/S0079-6123(07)00015-5.