PMID- 18395159
OWN - NLM
STAT- MEDLINE
DCOM- 20080604
LR  - 20121115
IS  - 1879-0828 (Electronic)
IS  - 0953-6205 (Linking)
VI  - 19
IP  - 3
DP  - 2008 May
TI  - Cardiac resynchronisation therapy: evidence based benefits and patient selection.
PG  - 165-72
LID - 10.1016/j.ejim.2007.09.012 [doi]
AB  - Despite the improvement in pharmacologic treatment of heart failure, many 
      patients continue to have severe persistent symptoms, and their prognosis remains 
      poor. One of the most recent advances in heart failure management is the concept 
      of cardiac resynchronization therapy (CRT) with right and left ventricular 
      pacing. Large clinical trials have demonstrated morbidity and mortality benefits 
      of CRT in patients with moderate to severe drug refractory heart failure (New 
      York Heart Association (NYHA) functional class III or IV), and ejection fraction 
      < or = 35% with QRS duration > or = 120 ms. Despite the documented benefits, 
      20-30% of patients selected to have CRT do not respond to this treatment. 
      Echocardiography will probably play a more important role in better selecting 
      patients with mechanical dyssynchrony who are more likely to respond to CRT. This 
      article reviews the available evidence for CRT as well as the way to select 
      responders to this rather invasive therapy.
FAU - Albouaini, K
AU  - Albouaini K
AD  - Cardiothoracic Centre, Liverpool, UK. Albouaini@aol.com
FAU - Egred, M
AU  - Egred M
FAU - Rao, A
AU  - Rao A
FAU - Alahmar, A
AU  - Alahmar A
FAU - Wright, D J
AU  - Wright DJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20071119
PL  - Netherlands
TA  - Eur J Intern Med
JT  - European journal of internal medicine
JID - 9003220
SB  - IM
MH  - Cardiac Catheterization
MH  - *Cardiac Pacing, Artificial/methods
MH  - *Evidence-Based Medicine
MH  - Heart Failure/diagnosis/mortality/*therapy
MH  - Humans
MH  - *Patient Selection
MH  - Prognosis
MH  - Prosthesis Implantation/methods
RF  - 40
EDAT- 2008/04/09 09:00
MHDA- 2008/06/05 09:00
CRDT- 2008/04/09 09:00
PHST- 2007/03/20 00:00 [received]
PHST- 2007/04/27 00:00 [revised]
PHST- 2007/09/26 00:00 [accepted]
PHST- 2008/04/09 09:00 [pubmed]
PHST- 2008/06/05 09:00 [medline]
PHST- 2008/04/09 09:00 [entrez]
AID - S0953-6205(07)00259-2 [pii]
AID - 10.1016/j.ejim.2007.09.012 [doi]
PST - ppublish
SO  - Eur J Intern Med. 2008 May;19(3):165-72. doi: 10.1016/j.ejim.2007.09.012. Epub 
      2007 Nov 19.