PMID- 18395922
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20111117
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 61
IP  - 2
DP  - 2008 Jun
TI  - Brain-derived neurotrophic factor-mediated retrograde signaling required for the 
      induction of long-term potentiation at inhibitory synapses of visual cortical 
      pyramidal neurons.
PG  - 192-200
LID - 10.1016/j.neures.2008.02.006 [doi]
AB  - High-frequency stimulation (HFS) induces long-term potentiation (LTP) at 
      inhibitory synapses of layer 5 pyramidal neurons in developing rat visual cortex. 
      This LTP requires postsynaptic Ca2+ rise for induction, while the maintenance 
      mechanism is present at the presynaptic site, suggesting presynaptic LTP 
      expression and the necessity of retrograde signaling. We investigated whether the 
      supposed signal is mediated by brain-derived neurotrophic factor (BDNF), which is 
      expressed in pyramidal neurons but not inhibitory interneurons. LTP did not occur 
      when HFS was applied in the presence of the Trk receptor tyrosine kinase 
      inhibitor K252a in the perfusion medium. HFS produced LTP when bath application 
      of K252a was started after HFS or when K252a was loaded into postsynaptic cells. 
      LTP did not occur in the presence of TrkB-IgG scavenging BDNF or 
      function-blocking anti-BDNF antibody in the medium. In cells loaded with the Ca2+ 
      chelator BAPTA, the addition of BDNF to the medium enabled HFS to induce LTP 
      without affecting baseline synaptic transmission. These results suggest that BDNF 
      released from postsynaptic cells activates presynaptic TrkB, leading to LTP. 
      Because BDNF, expressed activity dependently, regulates the maturation of 
      cortical inhibition, inhibitory LTP may contribute to this developmental process, 
      and hence experience-dependent functional maturation of visual cortex.
FAU - Inagaki, Tsuyoshi
AU  - Inagaki T
AD  - Department of Neuroscience, Research Institute of Environmental Medicine, Nagoya 
      University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
FAU - Begum, Tahamina
AU  - Begum T
FAU - Reza, Faruque
AU  - Reza F
FAU - Horibe, Shoko
AU  - Horibe S
FAU - Inaba, Mie
AU  - Inaba M
FAU - Yoshimura, Yumiko
AU  - Yoshimura Y
FAU - Komatsu, Yukio
AU  - Komatsu Y
LA  - eng
PT  - Journal Article
DEP - 20080302
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Indole Alkaloids)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/drug effects/*metabolism
MH  - Carbazoles/pharmacology
MH  - Electric Stimulation
MH  - Enzyme Inhibitors/pharmacology
MH  - Indole Alkaloids/pharmacology
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Organ Culture Techniques
MH  - Patch-Clamp Techniques
MH  - Pyramidal Cells/drug effects/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptor, trkB/metabolism
MH  - Signal Transduction/drug effects/*physiology
MH  - Synapses/drug effects/*physiology
MH  - Visual Cortex/drug effects/*physiology
EDAT- 2008/04/09 09:00
MHDA- 2008/07/30 09:00
CRDT- 2008/04/09 09:00
PHST- 2008/02/04 00:00 [received]
PHST- 2008/02/20 00:00 [revised]
PHST- 2008/02/25 00:00 [accepted]
PHST- 2008/04/09 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2008/04/09 09:00 [entrez]
AID - S0168-0102(08)00075-8 [pii]
AID - 10.1016/j.neures.2008.02.006 [doi]
PST - ppublish
SO  - Neurosci Res. 2008 Jun;61(2):192-200. doi: 10.1016/j.neures.2008.02.006. Epub 
      2008 Mar 2.