PMID- 18397187
OWN - NLM
STAT- MEDLINE
DCOM- 20080728
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 6
DP  - 2008 Jun
TI  - The presence of DRB1*01 allele in multiple myeloma patients is associated with an 
      indolent disease.
PG  - 548-51
LID - 10.1111/j.1399-0039.2008.01048.x [doi]
AB  - The human leukocyte antigen (HLA) system could play an essential role in multiple 
      myeloma (MM) disease control. This report describes the results comparing 
      HLA-DRB1 phenotypic frequencies in 181 MM patients (53 smoldering/indolent MM and 
      128 symptomatic MM patients) and healthy individuals. Higher DRB1*01 phenotypic 
      frequencies were found in the smoldering patients compared with symptomatic MM 
      patients (38% vs 14%, P = 0.001) and with the healthy individuals (38% vs 22%, P 
      = 0.01). Additionally, higher DRB1*07 phenotypic frequencies were found in 
      symptomatic MM compared with control population (38% vs 28%, P = 0.01). The 
      present data suggest that HLA-DRB1*01 individuals may have a better ability to 
      efficiently present myeloma-related antigens to immunocompetent cells, which 
      could favor a better immune response against the tumor. This would translate into 
      a more appropriate disease control associated with more indolent disease and 
      prolonged survival.
FAU - Alcoceba, M
AU  - Alcoceba M
AD  - Departamento de Hematologia, Hospital Universitario de Salamanca, Salamanca, 
      Spain.
FAU - Marin, L
AU  - Marin L
FAU - Balanzategui, A
AU  - Balanzategui A
FAU - Sarasquete, M E
AU  - Sarasquete ME
FAU - Martin-Jimenez, P
AU  - Martin-Jimenez P
FAU - Chillon, M C
AU  - Chillon MC
FAU - Corral, R
AU  - Corral R
FAU - Perez-Persona, E
AU  - Perez-Persona E
FAU - Fernandez-Calvo, F J
AU  - Fernandez-Calvo FJ
FAU - Hernandez, J M
AU  - Hernandez JM
FAU - Blade, J
AU  - Blade J
FAU - Lahuerta, J J
AU  - Lahuerta JJ
FAU - Gonzalez, M
AU  - Gonzalez M
FAU - San Miguel, J F
AU  - San Miguel JF
FAU - Garcia-Sanz, R
AU  - Garcia-Sanz R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20080407
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*01 antigen)
SB  - IM
MH  - Antigen Presentation/genetics/immunology
MH  - Female
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Multiple Myeloma/*genetics/immunology/mortality
MH  - Phenotype
EDAT- 2008/04/10 09:00
MHDA- 2008/07/29 09:00
CRDT- 2008/04/10 09:00
PHST- 2008/04/10 09:00 [pubmed]
PHST- 2008/07/29 09:00 [medline]
PHST- 2008/04/10 09:00 [entrez]
AID - TAN1048 [pii]
AID - 10.1111/j.1399-0039.2008.01048.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Jun;71(6):548-51. doi: 10.1111/j.1399-0039.2008.01048.x. 
      Epub 2008 Apr 7.