PMID- 18397279
OWN - NLM
STAT- MEDLINE
DCOM- 20080708
LR  - 20220409
IS  - 1365-2559 (Electronic)
IS  - 0309-0167 (Linking)
VI  - 52
IP  - 6
DP  - 2008 May
TI  - EGFR in gastric carcinomas: prognostic significance of protein overexpression and 
      high gene copy number.
PG  - 738-46
LID - 10.1111/j.1365-2559.2008.03021.x [doi]
AB  - AIMS: Epidermal growth factor receptor (EGFR) expression has been observed in a 
      variety of solid tumours with the potential of new targeted therapeutic agents. 
      The aim was to evaluate the EGFR status of gastric carcinoma (GC) using 
      immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). METHODS 
      AND RESULTS: The EGFR status was evaluated in GC tissues from 511 patients using 
      IHC and FISH. In addition, the clinicopathological characteristics were examined 
      and the results were compared with the EGFR status. One hundred and forty cases 
      (27.4%) showed EGFR overexpression by IHC. EGFR overexpression was associated 
      with older age (P = 0.001), moderately or poorly differentiated histology (P = 
      0.001) and higher stage disease (P = 0.046). Sixteen cases (3.1%) showed high 
      polysomy and 12 cases (2.3%) had gene amplification by FISH. The correlation 
      between IHC and FISH results was statistically significant (P < 0.001). The 
      patients with GC who had EGFR overexpression had an unfavourable prognosis and 
      multivariate analysis showed that EGFR overexpression was a possible independent 
      unfavourable prognostic factor. CONCLUSIONS: EGFR overexpression was observed in 
      a subset of cases with GC and was associated with an unfavourable prognosis. It 
      will be important to evaluate EGFR status to interpret future clinical trials 
      properly using EGFR targeted agents.
FAU - Kim, M A
AU  - Kim MA
AD  - Department of Pathology, Seoul National University College of Medicine, Seoul, 
      Korea.
FAU - Lee, H S
AU  - Lee HS
FAU - Lee, H E
AU  - Lee HE
FAU - Jeon, Y K
AU  - Jeon YK
FAU - Yang, H K
AU  - Yang HK
FAU - Kim, W H
AU  - Kim WH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080405
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Aged
MH  - Carcinoma/*diagnosis/genetics/metabolism
MH  - ErbB Receptors/*genetics/metabolism
MH  - Female
MH  - *Gene Dosage
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Stomach Neoplasms/*diagnosis/genetics/metabolism
MH  - Survival Analysis
EDAT- 2008/04/10 09:00
MHDA- 2008/07/09 09:00
CRDT- 2008/04/10 09:00
PHST- 2008/04/10 09:00 [pubmed]
PHST- 2008/07/09 09:00 [medline]
PHST- 2008/04/10 09:00 [entrez]
AID - HIS3021 [pii]
AID - 10.1111/j.1365-2559.2008.03021.x [doi]
PST - ppublish
SO  - Histopathology. 2008 May;52(6):738-46. doi: 10.1111/j.1365-2559.2008.03021.x. 
      Epub 2008 Apr 5.