PMID- 18397409
OWN - NLM
STAT- MEDLINE
DCOM- 20080602
LR  - 20220316
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 19
IP  - 3
DP  - 2008 May
TI  - Non-atopic asthma in children is related to maternal bronchial hyperreactivity.
PG  - 248-54
LID - 10.1111/j.1399-3038.2007.00620.x [doi]
AB  - Data on the pathogenic mechanisms underlying the development of non-atopic asthma 
      in children are scarce. Our aim was to evaluate the association and compare the 
      atopic status, pulmonary functions, bronchial hyperresponsiveness and serum total 
      immunoglobulin E (IgE) levels of parents of atopic and non-atopic asthmatic 
      children by using objective methods. Fifty-one asthmatic children aged 4-16 yr 
      and their parents were included into the study. Initially the American Thoracic 
      Society's Respiratory Disease questionnaire inquiring data on symptoms of asthma, 
      rhinitis and past medical history was filled in. Afterwards, skin prick test with 
      aeroallergens, pulmonary function and methacholine bronchial provocation tests 
      and serum sampling for total IgE level determinations were carried out. Bronchial 
      hyperresponsiveness to methacholine was significantly more common in the mothers 
      of non-atopic children compared to those of atopic ones, although no significant 
      difference was observed in the skin prick test reactivity, pulmonary function 
      test parameters and serum IgE levels. Questionnaire data revealed that the 
      presence of asthmatic symptoms such as wheezing and phlegm and doctor-diagnosed 
      asthma were more common in the mothers of non-atopic children. Meanwhile, 
      asthmatic symptoms were also found to be significantly more common in fathers of 
      non-atopic children. Logistic regression analyses revealed that maternal PC(20) 
      was the only predictive factor for the risk of displaying non-allergic asthma in 
      children. The results demonstrate that among the risk factors studied, maternal 
      bronchial hyperreactivity was associated with the development of asthma in 
      non-atopic children.
FAU - Ozdemir, Cevdet
AU  - Ozdemir C
AD  - Division of Pediatric Allergy and Immunology, Marmara University, Istanbul, 
      Turkey. cozdemir@superonline.com
FAU - Ceyhan, Berrin B
AU  - Ceyhan BB
FAU - Yazi, Didem
AU  - Yazi D
FAU - Eifan, Aarif O
AU  - Eifan AO
FAU - Yesil, Ozlem
AU  - Yesil O
FAU - Bahceciler, Nerin N
AU  - Bahceciler NN
FAU - Barlan, Isil B
AU  - Barlan IB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asthma/epidemiology/*genetics/immunology
MH  - Bronchial Hyperreactivity/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Family Health
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Rhinitis/epidemiology/*genetics/immunology
MH  - Risk Factors
EDAT- 2008/04/10 09:00
MHDA- 2008/06/03 09:00
CRDT- 2008/04/10 09:00
PHST- 2008/04/10 09:00 [pubmed]
PHST- 2008/06/03 09:00 [medline]
PHST- 2008/04/10 09:00 [entrez]
AID - 10.1111/j.1399-3038.2007.00620.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2008 May;19(3):248-54. doi: 
      10.1111/j.1399-3038.2007.00620.x.