PMID- 18397768
OWN - NLM
STAT- MEDLINE
DCOM- 20080819
LR  - 20111117
IS  - 1389-1723 (Print)
IS  - 1347-4421 (Linking)
VI  - 105
IP  - 3
DP  - 2008 Mar
TI  - Identification of HLA-A24-restricted epitopes with high affinities to Hsp70 using 
      peptide arrays.
PG  - 198-203
LID - 10.1263/jbb.105.198 [doi]
AB  - Heat shock protein 70 (Hsp70) family members are known as facilitators of immune 
      responses by interacting with receptors on antigen-presenting cells leading to 
      Hsp70-peptide uptake and antigen cross priming. Here, identification of human 
      leukocyte antigen (HLA)-A24-restricted epitopes was achieved using peptide arrays 
      for evaluation of their affinities to Hsp70 and HLA-A24 binding prediction tools. 
      Using Hsp70 as the model antigen, the GYPVTNAVI and VFQHGKVEI peptides were 
      identified as antigens. These peptides actually bound to HLA-A24 in the 
      stabilization assay using T2-A*2402 cells, and induced a strong peptide-reactive 
      cytotoxic T lymphocyte response in HLA-A24 transgenic mice after vaccination.
FAU - Okochi, Mina
AU  - Okochi M
AD  - Department of Biotechnology, School of Engineering, Nagoya University, Furo-cho, 
      Chikusa-ku, Nagoya 464-8603, Japan.
FAU - Hayashi, Hiroki
AU  - Hayashi H
FAU - Ito, Akira
AU  - Ito A
FAU - Kato, Ryuji
AU  - Kato R
FAU - Tamura, Yasuaki
AU  - Tamura Y
FAU - Sato, Noriyuki
AU  - Sato N
FAU - Honda, Hiroyuki
AU  - Honda H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Biosci Bioeng
JT  - Journal of bioscience and bioengineering
JID - 100888800
RN  - 0 (Epitopes)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A24 Antigen)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Oligopeptides)
SB  - IM
MH  - *Epitopes
MH  - HLA-A Antigens/*chemistry
MH  - HLA-A24 Antigen
MH  - HSP70 Heat-Shock Proteins/*chemistry
MH  - Humans
MH  - Oligopeptides/*chemistry
MH  - Protein Array Analysis
EDAT- 2008/04/10 09:00
MHDA- 2008/08/20 09:00
CRDT- 2008/04/10 09:00
PHST- 2007/08/23 00:00 [received]
PHST- 2007/11/28 00:00 [accepted]
PHST- 2008/04/10 09:00 [pubmed]
PHST- 2008/08/20 09:00 [medline]
PHST- 2008/04/10 09:00 [entrez]
AID - S1389-1723(08)70052-5 [pii]
AID - 10.1263/jbb.105.198 [doi]
PST - ppublish
SO  - J Biosci Bioeng. 2008 Mar;105(3):198-203. doi: 10.1263/jbb.105.198.